Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 6/20 | 0.55 |
| ▸ | HTR2C | P28335 | 6/20 | 0.55 |
| ▸ | HTR2B | P41595 | 4/20 | 0.53 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PPIA | P62937 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11966501 | 0.84 | KDR (0.52) | LMNAMAPTHTR2AHTR2CHTR2B | |
| SCHEMBL12692652 | 0.83 | HTR2C (0.50) | LMNAMAPTHTR2AHTR2CHTR2B | |
| SCHEMBL2481583 | 0.83 | HTR2A (0.64) | LMNAMAPTHTR2AHTR2CHTR2B | |
| SCHEMBL2435834 | 0.82 | PPIA (0.48) | MAPTHTTPPIAMEN1KMT2A | |
| SCHEMBL14458188 | 0.81 | NPC1 (0.67) | LMNAMAPTHTR2AHTR2CRIPK1 | |
| SCHEMBL4870653 | 0.81 | PDK1 (0.61) | LMNAMAPTPKMSMN1; SMN2PDK1 | |
| SCHEMBL3175847 | 0.80 | HTR2C (0.63) | LMNAMAPTHTR2AHTR2CHTR2B | |
| SCHEMBL8803891 | 0.80 | PDK1 (0.56) | PDK1PDK2PDK3PDK4NPC1 | |
| SCHEMBL14476382 | 0.79 | HTR2A (0.55) | LMNAMAPTHTR2AHTR2CHTR2B | |
| SCHEMBL14553225 | 0.79 | HTR2A (0.57) | LMNAHTR2AHTR2CHTR2BRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130005750-A1 | HETEROBICYCLIC CARBOXAMIDES AS INHIBITORS FOR KINASES | NOVARTIS AG (CH) | 2013-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130005750-A1 | HETEROBICYCLIC CARBOXAMIDES AS INHIBITORS FOR KINASES | CDK2, PHKG1, PHKG2 | LMNA 2744/4885MAPT 2302/4885HTR2A 3021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.