Sugi Predict

Sugi Predict / Compounds / SCHEMBL14482004

SCHEMBL14482004

SCHEMBL14482004

COC(=O)c1ccc(OCc2nc(-c3ccc(F)cc3)oc2Sc2ccc(Cl)cn2)cc1

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ FAAH O00519 2/20 0.51
▸ KCNH2 Q12809 2/20 0.51
▸ TP53 P04637 4/20 0.43
▸ POLB P06746 2/20 0.43
▸ PTPN7 P35236 1/20 0.42
▸ PPARG P37231 7/20 0.41
▸ PPARA Q07869 7/20 0.41
▸ MAPT P10636 2/20 0.40
▸ CETP P11597 1/20 0.40
▸ NPC1 O15118 1/20 0.40
▸ RAB9A P51151 1/20 0.40
▸ ESR1 P03372 1/20 0.40
▸ THRA P10827 1/20 0.40
▸ THRB P10828 1/20 0.40
▸ VDR P11473 1/20 0.40
▸ RXRA P19793 1/20 0.40
▸ PPARD Q03181 1/20 0.40
▸ ESR2 Q92731 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16881793 0.91 FAAH (0.52) FAAHKCNH2TP53POLBPPARG
SCHEMBL14482147 0.91 FAAH (0.50) FAAHKCNH2TP53POLBPPARG
SCHEMBL2594822 0.90 FAAH (0.51) FAAHKCNH2TP53POLBPPARG
SCHEMBL14482140 0.90 GABRA5 (0.50) FAAHKCNH2
SCHEMBL14482144 0.90 FAAH (0.49) FAAHKCNH2TP53POLBPPARG
SCHEMBL7714656 0.89 FAAH (0.49) FAAHKCNH2TP53POLBPPARG
SCHEMBL14482071 0.89 KCNH2 (0.50) FAAHKCNH2TP53POLBPPARG
SCHEMBL7716026 0.87 FAAH (0.50) FAAHKCNH2TP53PPARGPPARA
SCHEMBL14482324 0.87 FAAH (0.47) FAAHKCNH2TP53POLBMAPT
SCHEMBL14481925 0.86 FAAH (0.49) FAAHKCNH2TP53PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2593102-B1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH MERCK SHARP & DOHME (US) 2017-06-07 — — EP disclosed
EP-2593102-B1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH MERCK SHARP & DOHME (US) 2017-06-07 — — EP disclosed
US-9073879-B2 Oxazole derivatives useful as modulators of FAAH MERCK SHARP & DOHME CORP. (US) 2015-07-07 — — US disclosed
US-9073879-B2 Oxazole derivatives useful as modulators of FAAH MERCK SHARP & DOHME CORP. (US) 2015-07-07 — — US disclosed
US-9073879-B2 Oxazole derivatives useful as modulators of FAAH MERCK SHARP & DOHME CORP. (US) 2015-07-07 — — US disclosed
US-20130012526-A1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH MERCK SHARP & DOHME CORP. (US) 2013-01-10 — — US disclosed
US-20130012526-A1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH MERCK SHARP & DOHME CORP. (US) 2013-01-10 — — US disclosed
US-20130012526-A1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH MERCK SHARP & DOHME CORP. (US) 2013-01-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130012526-A1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH FAAH, FAAH2, ALOX5 FAAH 1/4885KCNH2 2461/4885TP53 4856/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.