SCHEMBL14485337

SCHEMBL14485337

Cc1ccc(N(C)CCNC(=O)O)nc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR3 P49019 2/20 0.49
CKS1B P61024 1/20 0.41
SKP1 P63208 1/20 0.41
SKP2 Q13309 1/20 0.41
HDAC1 Q13547 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
HDAC9 Q9UKV0 1/20 0.40
AOC3 Q16853 2/20 0.40
RAB9A P51151 2/20 0.39
MAPT P10636 1/20 0.39
HTT P42858 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
CNR1 P21554 1/20 0.38
PKM P14618 1/20 0.37
MTNR1A P48039 1/20 0.37
MTNR1B P49286 1/20 0.37
DGAT1 O75907 1/20 0.37
GAA P10253 1/20 0.37
MAPK1 P28482 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14485788 0.85 HCAR3 (0.47) HCAR3CKS1BSKP1SKP2HDAC1
SCHEMBL14484822 0.83 MTNR1A (0.45) HCAR3CKS1BSKP1SKP2HDAC1
SCHEMBL14554636 0.83 CKS1B (0.59) HCAR3CKS1BSKP1SKP2MAPT
SCHEMBL14484879 0.82 L3MBTL1 (0.56) HCAR3CKS1BSKP1SKP2AOC3
SCHEMBL14484916 0.82 HCAR3 (0.44) HCAR3CKS1BSKP1SKP2AOC3
SCHEMBL24576251 0.81 NOS2 (0.45) HCAR3HDAC1HDAC2HDAC6HDAC9
SCHEMBL838271 0.79 KMT2A (0.48) CKS1BSKP1SKP2HDAC1HDAC2
SCHEMBL9906944 0.77 POLB (0.51) HCAR3HDAC1HDAC2HDAC6HDAC9
SCHEMBL11663157 0.75 HRH4 (0.47) HCAR3MAPTSMN1; SMN2
SCHEMBL13103012 0.75 HRH3 (0.47) HCAR3HDAC1HDAC2HDAC6HDAC9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013006408-A1 COMPOUNDS AND METHODS TEMPERO PHARMACEUTICALS, INC. (US) 2013-01-10 WO disclosed