Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4852681 | 0.79 | HPGD (0.35) | ALDH1A1L3MBTL1HSD17B10KDM4ENPC1 | |
| SCHEMBL4848347 | 0.77 | CD44 (0.41) | TDP1CYP3A4 | |
| SCHEMBL4850501 | 0.75 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1HSD17B10KDM4ENPC1 | |
| Aniline SCHEMBL28164799 | 0.75 | NPC1 (0.41) | ALDH1A1HSD17B10NPC1RAB9ATDP1 | |
| SCHEMBL28096454 | 0.74 | NPC1 (0.47) | ALDH1A1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL14409165 | 0.72 | PABPC1 (0.35) | ALDH1A1 | |
| SCHEMBL25985762 | 0.71 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1HSD17B10KDM4ENPC1 | |
| SCHEMBL4849563 | 0.70 | HTR7 (0.51) | MAPT | |
| SCHEMBL3087574 | 0.66 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1HSD17B10KDM4ENPC1 | |
| SCHEMBL9754961 | 0.64 | PTGS1 (0.39) | ALDH1A1NPC1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7910734-B2 | Cell adhesion inhibitory action and cell infiltration inhibitory action; inflammatory, autoimmune diseases associated with adhesion and infiltration of leukocytes, inflammatory bowel disease, ulcerative colitis, Crohn's disease, irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosi | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-03-22 | — | — | US | disclosed |
| US-7910734-B2 | Cell adhesion inhibitory action and cell infiltration inhibitory action; inflammatory, autoimmune diseases associated with adhesion and infiltration of leukocytes, inflammatory bowel disease, ulcerative colitis, Crohn's disease, irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosi | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-03-22 | — | — | US | disclosed |
| US-7910734-B2 | Cell adhesion inhibitory action and cell infiltration inhibitory action; inflammatory, autoimmune diseases associated with adhesion and infiltration of leukocytes, inflammatory bowel disease, ulcerative colitis, Crohn's disease, irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosi | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-03-22 | — | — | US | disclosed |
| EP-1889827-B1 | PROCESS FOR PRODUCING [2-(3,3,5,5-TETRAMETHYLCYCLOHEXYL)PHENYL]PIPERAZINE | EISAI R&D MAN CO LTD (JP) | 2010-08-25 | — | — | EP | disclosed |
| US-20090163715-A1 | Intermediate in Production of [2-(3,3,5,5-Tetramethylcyclohexyl)phenyl]Piperazine Compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-25 | — | — | US | disclosed |
| US-20090163715-A1 | Intermediate in Production of [2-(3,3,5,5-Tetramethylcyclohexyl)phenyl]Piperazine Compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-25 | — | — | US | disclosed |
| US-20090163715-A1 | Intermediate in Production of [2-(3,3,5,5-Tetramethylcyclohexyl)phenyl]Piperazine Compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-25 | — | — | US | disclosed |
| US-20080161566-A1 | Crystal and Salt of 1-Cyclopropylmethyl-4-[2-(3,3,5,5-Tetramethylcyclohexyl)Phenyl]Piperazine | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-07-03 | — | — | US | disclosed |
| US-20080161566-A1 | Crystal and Salt of 1-Cyclopropylmethyl-4-[2-(3,3,5,5-Tetramethylcyclohexyl)Phenyl]Piperazine | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-07-03 | — | — | US | disclosed |
| US-20080161566-A1 | Crystal and Salt of 1-Cyclopropylmethyl-4-[2-(3,3,5,5-Tetramethylcyclohexyl)Phenyl]Piperazine | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-07-03 | — | — | US | disclosed |
| EP-1889827-A1 | INTERMEDIATE IN PRODUCTION OF [2-(3,3,5,5-TETRAMETHYLCYCLOHEXYL)PHENYL]PIPERAZINE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2008-02-20 | — | — | EP | disclosed |
| EP-1889827-A1 | INTERMEDIATE IN PRODUCTION OF [2-(3,3,5,5-TETRAMETHYLCYCLOHEXYL)PHENYL]PIPERAZINE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2008-02-20 | — | — | EP | disclosed |
| EP-1832580-A1 | CRYSTAL AND SALT OF 1-CYCLOPROPYLMETHYL-4-Ý2-(3,3,5,5)-TETRAMETHYLCYCLOHEXYL)PHENYL¨PIPERAZINE | Eisai R&D Management Co., Ltd. (JP) | 2007-09-12 | — | — | EP | disclosed |
| EP-1832580-A1 | CRYSTAL AND SALT OF 1-CYCLOPROPYLMETHYL-4-Ý2-(3,3,5,5)-TETRAMETHYLCYCLOHEXYL)PHENYL¨PIPERAZINE | Eisai R&D Management Co., Ltd. (JP) | 2007-09-12 | — | — | EP | disclosed |
| US-20060276465-A1 | 1,2-di(cyclic) substituted benzene compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2006-12-07 | — | — | US | disclosed |
| EP-0623113-B1 | PYRAZOLE CARBOXANILIDE FUNGICIDES | MONSANTO CO (US) | 1997-03-05 | — | — | EP | disclosed |
| US-5223526-A | For plants | MONSANTO COMPANY (US) | 1993-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163715-A1 | Intermediate in Production of [2-(3,3,5,5-Tetramethylcyclohexyl)phenyl]Piperazine Compound | ICAM1, HRH1, HRH2 | ALDH1A1 489/4885L3MBTL1 4129/4885HSD17B10 2543/4885 |
| US-20080161566-A1 | Crystal and Salt of 1-Cyclopropylmethyl-4-[2-(3,3,5,5-Tetramethylcyclohexyl)Phenyl]Piperazine | ICAM1, IL5, VCAM1 | ALDH1A1 1199/4885L3MBTL1 3721/4885HSD17B10 3606/4885 |
| US-20060276465-A1 | 1,2-di(cyclic) substituted benzene compounds | HRH3, CCR10, HRH1 | ALDH1A1 617/4885L3MBTL1 3780/4885HSD17B10 498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.