Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH5 | P11766 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 10/20 | 0.35 |
| ▸ | POLB | P06746 | 7/20 | 0.32 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL242291 | 0.85 | CYP2C19 (0.56) | ADH5CYP2C19ALDH1A1ATMMAPT | |
| SCHEMBL242849 | 0.84 | CYP2C19 (0.76) | ADH5CYP2C19ALDH1A1ATMMAPT | |
| SCHEMBL14488398 | 0.84 | ADH5 (0.64) | ADH5CYP2C19ALDH1A1ATMMAPT | |
| SCHEMBL244136 | 0.83 | CYP2C19 (0.58) | ADH5CYP2C19ALDH1A1ATMMAPT | |
| SCHEMBL246670 | 0.82 | ADH5 (0.71) | ADH5CYP2C19ALDH1A1MAPTPOLB | |
| SCHEMBL243674 | 0.81 | CYP2C19 (0.61) | ADH5CYP2C19ALDH1A1ATMMAPT | |
| SCHEMBL14488750 | 0.81 | ADH5 (0.52) | ADH5CYP2C19ALDH1A1ATMMAPT | |
| SCHEMBL243796 | 0.81 | CYP2C19 (0.72) | ADH5CYP2C19ALDH1A1ATMMAPT | |
| N6022 SCHEMBL29502874 | 0.80 | ADH5 (1.00) | ADH5CYP2C19MAPTPOLBTP53 | |
| N6022 SCHEMBL244480 | 0.80 | ADH5 (1.00) | ADH5CYP2C19MAPTPOLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140135396-A1 | Treatment of Acetaminophen-Induced Liver Damage by the Administration of Modulators of Nitric Oxide | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2014-05-15 | — | — | US | disclosed |
| WO-2013006658-A1 | TREATMENT OF ACETAMINOPHEN-INDUCED LIVER DAMAGE BY THE ADMINISTRATION OF MODULATORS OF NITRIC OXIDE | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2013-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140135396-A1 | Treatment of Acetaminophen-Induced Liver Damage by the Administration of Modulators of Nitric Oxide | OAT, NOS2, NOS3 | ADH5 172/4885CYP2C19 116/4885ALDH1A1 148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.