Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 5/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HRH1 | P35367 | 3/20 | 0.38 |
| ▸ | TACR2 | P21452 | 2/20 | 0.38 |
| ▸ | TACR1 | P25103 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MLNR | O43193 | 1/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.37 |
| ▸ | EED | O75530 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | HLA-A | P04439 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14488300 | 0.89 | FAAH (0.40) | FAAHMAPTLMNAKDM4EMEN1 | |
| SCHEMBL14488124 | 0.86 | FAAH (0.45) | HTR2AHTR2CFAAHHTR7HRH1 | |
| SCHEMBL14488441 | 0.85 | KDM4E (0.43) | HTR2AFAAHMAPTLMNAKDM4E | |
| SCHEMBL14486731 | 0.84 | FAAH (0.48) | FAAHHTR2BADRA1DADRA1ASIGMAR1 | |
| SCHEMBL14486549 | 0.84 | FAAH (0.48) | FAAHMAPTKCNH2ADRA1DADRA1A | |
| SCHEMBL14488219 | 0.84 | ALDH1A1 (0.47) | FAAHMAPTLMNAKDM4EHTR2B | |
| SCHEMBL14488116 | 0.83 | FAAH (0.47) | FAAHABCB1HTR1ADRD2DRD4 | |
| SCHEMBL14488207 | 0.83 | FAAH (0.47) | FAAHABCB1HTR1ADRD2DRD4 | |
| SCHEMBL14488364 | 0.82 | FAAH (0.45) | FAAHHTR7HTR1ADRD2DRD4 | |
| SCHEMBL14486342 | 0.82 | FAAH (0.48) | HTR2AHTR2CFAAHHTR7LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726470-A1 | 1, 2, 4 -THIADIAZOL- 5 -YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT NEURODEGENERATIVE DISEASES | reMynd NV (BE) | 2014-05-07 | — | — | EP | disclosed |
| WO-2013004642-A1 | 1, 2, 4 -THIADIAZOL- 5 -YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT NEURODEGENERATIVE DISEASES | REMYND NV (BE) | 2013-01-10 | — | — | WO | disclosed |