Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14486293 | 0.94 | SIGMAR1 (0.56) | HTR1AFAAHADRA1DADRA1AADRA1B | |
| SCHEMBL14486444 | 0.94 | HTR1A (0.61) | HTR1AADRA1DADRA1AADRA1BSIGMAR1 | |
| SCHEMBL14486440 | 0.90 | HTR1A (0.56) | HTR1AADRA1DADRA1AADRA1BSIGMAR1 | |
| SCHEMBL14486394 | 0.87 | SIGMAR1 (0.59) | HTR1AFAAHADRA1DADRA1AADRA1B | |
| SCHEMBL14486031 | 0.86 | SIGMAR1 (0.57) | HTR1AFAAHADRA1DADRA1AADRA1B | |
| SCHEMBL14486630 | 0.85 | SIGMAR1 (0.56) | HTR1AFAAHADRA1DADRA1AADRA1B | |
| SCHEMBL14488116 | 0.85 | FAAH (0.47) | HTR1AFAAHADRA1DADRA1AADRA1B | |
| SCHEMBL14488207 | 0.85 | FAAH (0.47) | HTR1AFAAHADRA1DADRA1AADRA1B | |
| SCHEMBL14486500 | 0.85 | SIGMAR1 (0.60) | HTR1AFAAHADRA1DADRA1AADRA1B | |
| SCHEMBL14486130 | 0.84 | SIGMAR1 (0.55) | HTR1AFAAHADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726470-A1 | 1, 2, 4 -THIADIAZOL- 5 -YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT NEURODEGENERATIVE DISEASES | reMynd NV (BE) | 2014-05-07 | — | — | EP | disclosed |
| WO-2013004642-A1 | 1, 2, 4 -THIADIAZOL- 5 -YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT NEURODEGENERATIVE DISEASES | REMYND NV (BE) | 2013-01-10 | — | — | WO | disclosed |