Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.47 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14488787 | 0.85 | OPRM1 (0.48) | OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL14489288 | 0.80 | DRD3 (0.41) | DRD2 | |
| SCHEMBL13899948 | 0.71 | OPRK1 (0.47) | OPRM1OPRD1OPRK1ESR2DRD2 | |
| SCHEMBL14489310 | 0.71 | OPRK1 (0.47) | OPRM1OPRD1OPRK1ESR2DRD2 | |
| SCHEMBL29427014 | 0.70 | DRD2 (0.59) | DRD2 | |
| SCHEMBL1608042 | 0.70 | DRD2 (0.59) | DRD2 | |
| SCHEMBL14489160 | 0.69 | OPRM1 (0.42) | OPRM1SLC22A12ESR2 | |
| SCHEMBL8527088 | 0.69 | OPRM1 (0.42) | OPRM1SLC22A12ESR2 | |
| SCHEMBL14489380 | 0.69 | DRD2 (0.40) | DRD2 | |
| SCHEMBL10685365 | 0.69 | SLC22A12 (0.72) | OPRM1OPRD1OPRK1SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007073503-A2 | INDANE MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-28 | — | — | WO | disclosed |