Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.48 |
| ▸ | DRD1 | P21728 | 5/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14489147 | 0.85 | OPRM1 (0.47) | OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL14489223 | 0.82 | SLC22A12 (0.59) | DRD1HSD17B10DRD5 | |
| SCHEMBL14489450 | 0.81 | TRPM5 (0.49) | HTR2A | |
| SCHEMBL14489203 | 0.81 | DRD5 (0.38) | DRD5 | |
| SCHEMBL14488814 | 0.80 | ALDH1A1 (0.44) | ALDH1A1GAA | |
| SCHEMBL8527088 | 0.80 | OPRM1 (0.42) | OPRM1 | |
| SCHEMBL14489160 | 0.80 | OPRM1 (0.42) | OPRM1 | |
| SCHEMBL7912606 | 0.79 | SIGMAR1 (0.49) | OPRM1OPRK1HTR2A | |
| SCHEMBL14489319 | 0.79 | MAPT (0.41) | DRD2ALDH1A1HPGDDRD5 | |
| SCHEMBL14489216 | 0.78 | OPRM1 (0.50) | OPRM1OPRD1OPRK1HTR2ADRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007073503-A2 | INDANE MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-28 | — | — | WO | disclosed |