Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 19/20 | 0.51 |
| ▸ | THRA | P10827 | 15/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14489180 | 0.91 | THRB (0.51) | THRBTHRA | |
| SCHEMBL14488902 | 0.84 | THRB (0.70) | THRBTHRA | |
| SCHEMBL6853009 | 0.83 | THRA (0.45) | THRBTHRAMMP1MMP2MMP3 | |
| SCHEMBL14489092 | 0.83 | THRB (0.64) | THRBTHRA | |
| SCHEMBL14488964 | 0.82 | THRB (0.62) | THRBTHRA | |
| SCHEMBL14489095 | 0.81 | THRB (0.42) | THRBTHRA | |
| SCHEMBL14489239 | 0.79 | THRB (0.53) | THRBTHRA | |
| SCHEMBL6852992 | 0.79 | THRA (0.57) | THRBTHRA | |
| SCHEMBL14489245 | 0.78 | THRB (0.55) | THRBTHRA | |
| SCHEMBL14489241 | 0.78 | THRB (0.51) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230031-B2 | Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2007-06-12 | — | — | US | disclosed |