Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 5/20 | 0.61 |
| ▸ | DRD4 | P21917 | 4/20 | 0.61 |
| ▸ | DRD5 | P21918 | 4/20 | 0.61 |
| ▸ | DRD2 | P14416 | 3/20 | 0.61 |
| ▸ | MAOA | P21397 | 4/20 | 0.52 |
| ▸ | MAOB | P27338 | 4/20 | 0.52 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12363783 | 0.83 | DRD5 (0.66) | DRD1DRD4DRD5DRD2MAOA | |
| SCHEMBL27001379 | 0.80 | DRD2 (0.43) | DRD1DRD4DRD5DRD2MAOA | |
| SCHEMBL25452935 | 0.77 | DRD2 (0.42) | DRD1DRD4DRD5DRD2MAOA | |
| SCHEMBL19163952 | 0.77 | DRD2 (0.42) | DRD1DRD4DRD5DRD2MAOA | |
| SCHEMBL8312582 | 0.73 | DRD2 (0.46) | DRD1DRD4DRD5DRD2MAOA | |
| SCHEMBL16062597 | 0.72 | MAOA (0.41) | DRD1DRD4DRD5DRD2MAOA | |
| SCHEMBL5083188 | 0.71 | DRD2 (0.47) | DRD1DRD4DRD5DRD2HTR5A | |
| SCHEMBL13326543 | 0.71 | — | — | |
| SCHEMBL13415331 | 0.70 | DRD2 (0.46) | DRD1DRD4DRD5DRD2HTR5A | |
| SCHEMBL29391320 | 0.69 | DRD1 (0.85) | DRD1DRD4DRD5DRD2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |
| WO-2007071840-A2 | COMPOUNDS BASED ON FOUR AROMATIC RINGS, PREPARATION AND USES THEREOF | CEREP (FR) | 2007-06-28 | — | — | WO | disclosed |