Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 5/20 | 0.41 |
| ▸ | NOS2 | P35228 | 4/20 | 0.41 |
| ▸ | NOS3 | P29474 | 3/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | CFD | P00746 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 3/20 | 0.35 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | OGT | O15294 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3548193 | 0.79 | ERCC5 (0.53) | NOS1NOS2NOS3F2CFD | |
| SCHEMBL25541170 | 0.77 | NOS1 (0.43) | NOS1NOS2NOS3F2CFD | |
| SCHEMBL14403068 | 0.75 | F2 (0.34) | NOS1NOS2NOS3F2CFD | |
| SCHEMBL13392528 | 0.73 | PKM (0.33) | NPSR1PKMPKLR | |
| SCHEMBL1523074 | 0.71 | ERCC5 (0.54) | NOS1F2CFDPDGFRAMAPK8 | |
| SCHEMBL3932932 | 0.70 | F2 (0.39) | NOS1NOS2NOS3F2CFD | |
| SCHEMBL4214560 | 0.69 | CDC7 (0.51) | PKMPKLRERCC5FEN1 | |
| SCHEMBL19427807 | 0.67 | ALDH1A1 (0.37) | PKMPKLR | |
| SCHEMBL27398191 | 0.66 | ADORA2B (0.43) | LMNATSHRBLMPKMPKLR | |
| SCHEMBL10618031 | 0.65 | F2 (0.50) | NOS1NOS2NOS3F2CFD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235566-B2 | Pyridinone derivatives for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2007-06-26 | — | — | US | disclosed |
| US-7235566-B2 | Pyridinone derivatives for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2007-06-26 | — | — | US | disclosed |