Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 1/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.37 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31734535 | 0.93 | PTP4A3 (0.38) | ABCC9ABCC8KCNJ11KCNJ8AR | |
| SCHEMBL19101464 | 0.84 | TRPV4 (0.46) | ARACMSDMAOAMAOBTRPV4 | |
| SCHEMBL5109838 | 0.82 | QDPR (0.50) | DRD2DRD3PLA2G7 | |
| SCHEMBL17202487 | 0.82 | TRPV4 (0.47) | ARDRD2DRD3TRPV4PGR | |
| SCHEMBL27718553 | 0.81 | MAOA (0.53) | ARDRD2DRD3ACMSDMAOA | |
| SCHEMBL9405293 | 0.79 | CYP2C9 (0.45) | ABCC9ABCC8KCNJ11KCNJ8AR | |
| SCHEMBL9405294 | 0.79 | CYP2C9 (0.45) | ABCC9ABCC8KCNJ11KCNJ8AR | |
| SCHEMBL11963260 | 0.78 | TRPV4 (0.50) | TRPV4 | |
| SCHEMBL8768442 | 0.77 | TRPV4 (0.42) | ARMAOAMAOBTRPV4PGR | |
| SCHEMBL2926803 | 0.77 | DRD2 (0.57) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235575-B2 | Guanidine mimics as factor Xa inhibitors | BRISTOL MYERS SQUIBB COMPANY (US) | 2007-06-26 | — | — | US | disclosed |