Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12530528 | 0.88 | TSHR (0.50) | L3MBTL1TSHRLOXL2KDM4EALDH1A1 | |
| SCHEMBL20739187 | 0.79 | TSHR (0.54) | L3MBTL1TSHRKDM4EALDH1A1 | |
| SCHEMBL92354 | 0.78 | CA1 (0.44) | TSHRALDH1A1 | |
| SCHEMBL739465 | 0.78 | LOXL2 (0.41) | L3MBTL1TSHRLOXL2KDM4EALDH1A1 | |
| SCHEMBL12793983 | 0.77 | CHRNA7 (0.52) | L3MBTL1CYP1A2CYP2D6HRH1TDP1 | |
| SCHEMBL14499021 | 0.77 | CYP1A2 (0.46) | ALDH1A1CYP1A2CYP3A4HRH3 | |
| SCHEMBL6750266 | 0.76 | LOXL2 (0.42) | L3MBTL1LOXL2LTA4HKDM4EALDH1A1 | |
| SCHEMBL5402692 | 0.76 | LOXL2 (0.50) | L3MBTL1LOXL2LTA4HKDM4EALDH1A1 | |
| SCHEMBL7328833 | 0.75 | LMNA (0.30) | — | |
| SCHEMBL21322106 | 0.75 | TSHR (0.32) | L3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920063-B2 | Melampomagnolide B derivatives | BIOVENTURES, LLC (US) | 2018-03-20 | — | — | US | disclosed |
| US-9920063-B2 | Melampomagnolide B derivatives | BIOVENTURES, LLC (US) | 2018-03-20 | — | — | US | disclosed |
| US-9908892-B2 | Melampomagnolide B derivatives | BIOVENTURES, LLC (US) | 2018-03-06 | — | — | US | disclosed |
| US-9908892-B2 | Melampomagnolide B derivatives | BIOVENTURES, LLC (US) | 2018-03-06 | — | — | US | disclosed |
| US-20160368929-A1 | MELAMPOMAGNOLIDE B DERIVATIVES | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (US) | 2016-12-22 | — | — | US | disclosed |
| US-20160368928-A1 | MELAMPOMAGNOLIDE B DERIVATIVES | BIOVENTURES, LLC | 2016-12-22 | — | — | US | disclosed |
| US-9487536-B2 | Melampomagnolide B derivatives | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (US) | 2016-11-08 | — | — | US | disclosed |
| US-9469650-B2 | Melampomagnolide B derivatives | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (US) | 2016-10-18 | — | — | US | disclosed |
| US-20150203508-A1 | MELAMPOMAGNOLIDE B DERIVATIVES | BIOVENTURES, LLC | 2015-07-23 | — | — | US | disclosed |
| US-20150133444-A1 | MELAMPOMAGNOLIDE B DERIVATIVES | BIOVENTURES, LLC | 2015-05-14 | — | — | US | disclosed |
| US-7226950-B2 | Sodium channel modulators | THERAVANCE, INC. (US) | 2007-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150203508-A1 | MELAMPOMAGNOLIDE B DERIVATIVES | CMBL, MGMT, MMAB | L3MBTL1 987/4885TSHR 1050/4885LOXL2 4500/4885 |
| US-20150133444-A1 | MELAMPOMAGNOLIDE B DERIVATIVES | CMBL, STK32B, MMAB | L3MBTL1 905/4885TSHR 976/4885LOXL2 4599/4885 |
| US-20160368928-A1 | MELAMPOMAGNOLIDE B DERIVATIVES | CMBL, MGMT, MMAB | L3MBTL1 987/4885TSHR 1050/4885LOXL2 4500/4885 |
| US-20160368929-A1 | MELAMPOMAGNOLIDE B DERIVATIVES | CMBL, STK32B, MMAB | L3MBTL1 905/4885TSHR 976/4885LOXL2 4599/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.