Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | LOX | P28300 | 2/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11471530 | 0.88 | MBTD1 (0.51) | ALDH1A1CYP3A4CYP2C9CYP2C19MBTD1 | |
| SCHEMBL11471531 | 0.87 | MBTD1 (0.50) | ALDH1A1CYP3A4CYP2C9CYP2C19MBTD1 | |
| SCHEMBL14538078 | 0.86 | ALDH1A1 (0.57) | ALDH1A1CYP3A4CYP2C9CYP2C19MBTD1 | |
| SCHEMBL11532514 | 0.86 | EPHX2 (0.60) | ALDH1A1CYP3A4CYP2C9CYP2C19MAPK1 | |
| SCHEMBL14304331 | 0.84 | LOX (0.60) | ALDH1A1CYP3A4CYP2C9MBTD1L3MBTL1 | |
| SCHEMBL2494859 | 0.84 | SIGMAR1 (0.57) | ALDH1A1MBTD1L3MBTL1LOXMEN1 | |
| SCHEMBL19274818 | 0.84 | HRH3 (0.64) | MBTD1L3MBTL1LOXHRH3 | |
| SCHEMBL14490130 | 0.83 | MEN1 (0.55) | ALDH1A1MBTD1L3MBTL1LOXMEN1 | |
| SCHEMBL11569125 | 0.81 | MEN1 (0.57) | ALDH1A1CYP3A4CYP2C9CYP2C19MAPK1 | |
| SCHEMBL15434577 | 0.79 | ALDH1A1 (0.62) | ALDH1A1CYP3A4CYP2C9CYP2C19MBTD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070149508-A1 | Six membered heteroaromatic inhibitors targeting resistant kinase mutations | TARGEGEN, INC. (US) | 2007-06-28 | — | — | US | disclosed |
| WO-2007056075-A2 | SIX MEMBERED HETEROAROMATIC INHIBITORS TARGETING RESISTANT KINASE MUTATIONS | TARGEGEN, INC. (US) | 2007-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149508-A1 | Six membered heteroaromatic inhibitors targeting resistant kinase mutations | ABL1, KDR, BCR | ALDH1A1 3322/4885CYP3A4 1786/4885CYP2C9 1652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.