Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOX | P28300 | 2/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL56319 | 0.89 | LOX (0.57) | LOXHRH3KCNH2GAALMNA | |
| SCHEMBL19274818 | 0.87 | HRH3 (0.64) | LOXHRH3KCNH2EPHX2MBTD1 | |
| SCHEMBL14501826 | 0.86 | LOX (0.51) | LOXEPHX2GAALMNAHTR6 | |
| SCHEMBL14502091 | 0.84 | ALDH1A1 (0.62) | LOXHRH3MBTD1L3MBTL1GAA | |
| SCHEMBL2494859 | 0.84 | SIGMAR1 (0.57) | LOXHRH3KCNH2EPHX2MBTD1 | |
| SCHEMBL14490130 | 0.83 | MEN1 (0.55) | LOXHRH3KCNH2EPHX2MBTD1 | |
| SCHEMBL2492457 | 0.79 | SRC (0.49) | LOXHRH3KCNH2EPHX2 | |
| SCHEMBL29980399 | 0.78 | GAA (0.61) | GAALMNAMPOCYP3A4CYP2C9 | |
| SCHEMBL7798812 | 0.77 | LMNA (0.51) | LOXGAALMNATSHRALDH1A1 | |
| SCHEMBL1636286 | 0.77 | L3MBTL1 (0.74) | MBTD1L3MBTL1GAAHTR7LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481536-B2 | Benzotriazine inhibitors of kinases | TARGEGEN, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| EP-2543376-A1 | Benzotriazine inhibitors of kinases | Targegen, Inc. (US) | 2013-01-09 | — | — | EP | disclosed |
| WO-2008008234-A1 | 2-AMINO-5-SUBSTITUTED PYRIMIDINE INHIBITORS | TARGEGEN, INC. (US) | 2008-01-17 | — | — | WO | disclosed |