Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 1/20 | 0.52 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.52 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.52 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2593928 | 0.81 | GRM1 (0.47) | ARKDM4EHSD17B10TTRACE2 | |
| SCHEMBL8402587 | 0.80 | LMNA (0.53) | LMNARAB9AMAPK1HTTEGLN1 | |
| SCHEMBL9321426 | 0.77 | TSHR (0.45) | KDM4EHSD17B10ACE2CA12CA1 | |
| SCHEMBL15331499 | 0.77 | KCNQ3 (0.41) | KCNQ3KCNQ2KCNE1KCNQ1LMNA | |
| SCHEMBL7439757 | 0.73 | CA12 (0.59) | LMNARAB9AMAPK1HTTKDM4E | |
| SCHEMBL10896690 | 0.73 | LMNA (0.46) | LMNARAB9AMAPK1HTTSLC22A12 | |
| SCHEMBL2627846 | 0.73 | ACE2 (0.56) | LMNARAB9AMAPK1HTTKDM4E | |
| SCHEMBL25465991 | 0.72 | ALDH1A1 (0.47) | KCNQ3KCNQ2LMNARAB9AMAPK1 | |
| SCHEMBL23896809 | 0.71 | LMNA (0.51) | LMNARAB9AMAPK1HTTKDM4E | |
| SCHEMBL8102005 | 0.71 | CA2 (0.55) | LMNARAB9AMAPK1HTTSLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205307-B2 | Pyrimidines as novel openers of potassium ion channels | ICAGEN, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-7205307-B2 | Pyrimidines as novel openers of potassium ion channels | ICAGEN, INC. (US) | 2007-04-17 | — | — | US | disclosed |