Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 5/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.40 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14519874 | 0.82 | L3MBTL1 (0.60) | ALDH1A1NPSR1SMN1; SMN2LMNAGAA | |
| SCHEMBL14866325 | 0.81 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2GAAL3MBTL1NPC1 | |
| SCHEMBL9881333 | 0.79 | SMN1; SMN2 (0.53) | ALDH1A1NPSR1SMN1; SMN2LMNAHPGD | |
| SCHEMBL8295570 | 0.78 | ALDH1A1 (0.51) | ALDH1A1NPSR1SMN1; SMN2LMNAHPGD | |
| SCHEMBL28188560 | 0.78 | ALDH1A1 (0.48) | ALDH1A1NPSR1SMN1; SMN2LMNAHPGD | |
| SCHEMBL8300776 | 0.78 | POLB (0.49) | ALDH1A1NPSR1SMN1; SMN2LMNAHPGD | |
| SCHEMBL14866241 | 0.77 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2GAAL3MBTL1NPC1 | |
| SCHEMBL14464889 | 0.77 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2LMNAHPGDGAA | |
| SCHEMBL14866258 | 0.76 | TXNRD1 (0.54) | ALDH1A1SMN1; SMN2LMNAPOLBRAB9A | |
| SCHEMBL31213824 | 0.75 | L3MBTL1 (0.70) | ALDH1A1NPSR1SMN1; SMN2LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070078146-A1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | PHARMACIA CORPORATION | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078146-A1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | MAPK1, MAPK3, MAPK4 | ALDH1A1 1079/4885NPSR1 3274/4885SMN1; SMN2 2049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.