Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.44 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.44 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | MPL | P40238 | 1/20 | 0.44 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1817467 | 0.85 | PKM (0.55) | GAAALDH1A1NPSR1SMN1; SMN2LMNA | |
| SCHEMBL10497795 | 0.83 | SMN1; SMN2 (0.54) | GAAALDH1A1NPSR1SMN1; SMN2LMNA | |
| SCHEMBL12736825 | 0.83 | PKM (0.54) | GAAALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL9881333 | 0.82 | SMN1; SMN2 (0.53) | POLBGAATSHRALDH1A1NPSR1 | |
| SCHEMBL9121788 | 0.82 | ALDH1A1 (0.44) | POLBGAATSHRALDH1A1NPSR1 | |
| SCHEMBL8295570 | 0.81 | ALDH1A1 (0.51) | POLBGAATSHRALDH1A1NPSR1 | |
| SCHEMBL28188560 | 0.81 | ALDH1A1 (0.48) | POLBGAATSHRALDH1A1NPSR1 | |
| SCHEMBL2336447 | 0.81 | ERN1 (0.50) | POLBGAAALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL30965843 | 0.81 | L3MBTL1 (0.64) | GAAALDH1A1NPSR1SMN1; SMN2LMNA | |
| SCHEMBL668653 | 0.81 | L3MBTL1 (0.64) | GAAALDH1A1NPSR1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107074827-B | Pladienolide pyridine compounds and methods of use | 卫材研究发展管理有限公司 | 2020-12-18 | — | — | CN | claimed |
| US-20250333400-A1 | CERTAIN PLADIENOLIDE COMPOUNDS AND METHODS OF USE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2025-10-30 | — | — | US | disclosed |
| CN-119462594-A | Pradienolide compound and application thereof | 卫材R&D管理有限公司 | 2025-02-18 | — | — | CN | disclosed |
| US-20240368140-A1 | CERTAIN PLADIENOLIDE COMPOUNDS AND METHODS OF USE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2024-11-07 | — | — | US | disclosed |
| US-20240350484-A1 | METHODS OF USING SPLICING MODULATORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2024-10-24 | — | — | US | disclosed |
| EP-3801523-B1 | SPLICING MODULATORS | EISAI R&D MAN CO LTD (JP) | 2024-09-11 | — | — | EP | disclosed |
| US-11998544-B2 | Methods of using splicing modulators | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2024-06-04 | — | — | US | disclosed |
| CN-112367996-B | Methods of using splice modulators | 卫材R&D管理有限公司 | 2024-05-24 | — | — | CN | disclosed |
| CN-108473479-B | Solid state forms of pladienolide pyridine compounds and methods of use | 卫材研究发展管理有限公司 | 2024-05-07 | — | — | CN | disclosed |
| US-11926619-B2 | Certain pladienolide compounds and methods of use | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2024-03-12 | — | — | US | disclosed |
| US-7217803-B2 | Benzimidazole-pyridone-based azo dyes | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2007-05-15 | — | — | US | disclosed |
| US-7217803-B2 | Benzimidazole-pyridone-based azo dyes | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2007-05-15 | — | — | US | disclosed |
| WO-2007039573-A2 | AZO REACTIVE DYES AND MIXTURES OF FIBER-REACTIVE AZO DYES, THEIR PREPARATION AND THEIR USE | DYSTAR TEXTILFARBEN GMBH & CO DEUTSCHLAND KG (DE) | 2007-04-12 | — | — | WO | disclosed |
| US-7183409-B2 | Basic mono- and bisazo compounds | CLARIANT FINANCE (BVI) LIMITED (VG) | 2007-02-27 | — | — | US | disclosed |
| US-7183409-B2 | Basic mono- and bisazo compounds | CLARIANT FINANCE (BVI) LIMITED (VG) | 2007-02-27 | — | — | US | disclosed |
| WO-2007003524-A1 | DISAZO DYES AND DYE COMPOSITIONS FOR SHADING WHITE PAPER | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2007-01-11 | — | — | WO | disclosed |
| EP-0799195-B1 | PROCESS FOR THE PREPARATION OF AROMATIC O-SULFOCARBOXYLIC ACIDS AND SULFONYLUREAS | NOVARTIS AG (CH) | 1999-04-14 | — | — | EP | disclosed |
| US-5883253-A | Process for the preparation of aromatic O-sulfocarboxylic acids and sulfonylureas | NOVARTIS AG (CH) | 1999-03-16 | — | — | US | disclosed |
| EP-0799195-A1 | PROCESS FOR THE PREPARATION OF AROMATIC O-SULFOCARBOXYLIC ACIDS AND SULFONYLUREAS | Novartis AG (CH) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019443-A1 | PROCESS FOR THE PREPARATION OF AROMATIC O-SULFOCARBOXYLIC ACIDS AND SULFONYLUREAS | NOVARTIS AG (CH) | 1996-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240368140-A1 | CERTAIN PLADIENOLIDE COMPOUNDS AND METHODS OF USE | PLAAT5, PLAAT3, PLAAT4 | POLB 1222/4885GAA 521/4885TSHR 4565/4885 |
| US-20250333400-A1 | CERTAIN PLADIENOLIDE COMPOUNDS AND METHODS OF USE | SNRPE, SNRPB2, DDX21 | POLB 1292/4885GAA 1550/4885TSHR 4772/4885 |
| US-20240350484-A1 | METHODS OF USING SPLICING MODULATORS | SF3B1, RBM17, SF3B5 | POLB 566/4885GAA 1974/4885TSHR 4220/4885 |
| US-11998544-B2 | Methods of using splicing modulators | SF3B1, RBM17, SF3B5 | POLB 566/4885GAA 1974/4885TSHR 4220/4885 |
| US-11926619-B2 | Certain pladienolide compounds and methods of use | PLAAT5, PLAAT3, PLAAT4 | POLB 1222/4885GAA 521/4885TSHR 4565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.