Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14524422 | 0.89 | MAPT (0.42) | SIRT6HIF1AALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL6996866 | 0.82 | GPR35 (0.42) | HIF1AGPR35MAPK1ALDH1A1TP53 | |
| SCHEMBL4406652 | 0.78 | ESR1 (0.34) | SIRT6GPR35MAPK1ALDH1A1TP53 | |
| SCHEMBL14524430 | 0.74 | ALDH1A1 (0.42) | ALDH1A1HPGDMAPTCHRNB4CHRNA3 | |
| SCHEMBL8018390 | 0.72 | CHRNB4 (0.38) | ALDH1A1HPGDTSHRRAB9AMAPT | |
| SCHEMBL29761227 | 0.70 | CHRNB4 (0.36) | ALDH1A1HPGDTSHRRAB9AMAPT | |
| SCHEMBL25735077 | 0.70 | CHRNB4 (0.36) | ALDH1A1HPGDTSHRRAB9AMAPT | |
| SCHEMBL6392586 | 0.70 | CYP2C9 (0.35) | GPR35MAPK1ALDH1A1TP53HPGD | |
| SCHEMBL30897542 | 0.69 | SIRT6 (0.53) | SIRT6HIF1AGPR35MAPK1ALDH1A1 | |
| SCHEMBL1903629 | 0.68 | CYP2C9 (0.35) | ALDH1A1MAPTCHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205300-B2 | Aryl fused azapolycyclic compounds | PFIZER INC (US) | 2007-04-17 | — | — | US | disclosed |