SCHEMBL145276

SCHEMBL145276

CC(C)(N=C=O)c1ccccc1C(C)(C)N=C=O

nearest known ligand 0.34

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.34
TSHR P16473 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
CYP3A4 P08684 1/20 0.32
CA2 P00918 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
GABRA1 P14867 1/20 0.30
GABRB2 P47870 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29483754 1.00 ALDH1A1 (0.34) ALDH1A1TSHRTDP1CYP3A4CA2
Hexamethylbenzene SCHEMBL28232121 0.94 CYP3A4 (0.38) ALDH1A1TSHRTDP1CYP3A4
SCHEMBL6831708 0.87 GABRA1 (0.35) ALDH1A1TSHRTDP1CYP3A4GABRA1
SCHEMBL11038317 0.85 CYP3A4 (0.33) CYP3A4CA2GABRA1GABRB2
SCHEMBL6704455 0.84 CYP3A4 (0.47) ALDH1A1TDP1CYP3A4GABRA1GABRB2
SCHEMBL7096568 0.82 CYP3A4 (0.41) ALDH1A1TSHRCYP3A4CA2GABRA1
SCHEMBL31485790 0.82 CYP3A4 (0.41) ALDH1A1TSHRCYP3A4CA2GABRA1
SCHEMBL10897571 0.82 ALDH1A1 (0.36) ALDH1A1TSHRTDP1CYP3A4CA2
SCHEMBL1348520 0.81 ALDH1A1 (0.34) ALDH1A1TSHRTDP1
SCHEMBL21117 0.80 MEN1 (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2797 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120137139-A Bis (1-isocyanato-1-methylethyl) benzene composition and preparation method and application thereof 万华化学集团股份有限公司 2025-06-13 CN claimed
CN-109642010-A The synthetic method of poly- Oxazolidinone compound 科思创德国股份有限公司 2019-04-16 CN claimed
CN-109244543-A A kind of lithium-ion battery electrolytes and lithium ion battery 南通新宙邦电子材料有限公司 2019-01-18 CN claimed
EP-2853527-B1 NOVEL METHOD FOR PREPARING POLYTHIOL COMPOUND AND POLYMERIC COMPOSITION FOR OPTICAL MATERIAL COMPRISING SAME KOC SOLUTION CO LTD (KR) 2018-09-19 EP claimed
EP-2660260-B1 COMPOSITION FOR OPTICAL MATERIAL MITSUBISHI GAS CHEMICAL CO (JP) 2018-09-12 EP claimed
US-10011734-B2 Coated film MITSUBISHI CHEMICAL CORPORATION (JP) 2018-07-03 US claimed
US-9994667-B2 Polythiourethane-based casting resin having high fracture resistance and low specific weight Bruno Bock Chemische Fabrik GmbH and Co. KG (DE) 2018-06-12 US claimed
US-9522879-B2 Method for preparing polythiol compound and polymeric composition for optical material comprising same KOC SOLUTION CO., LTD (KR) 2016-12-20 US claimed
EP-3080180-A1 POLYURETHANE UREA-CONTAINING COMPOSITIONS AND OPTICAL ARTICLES AND METHODS FOR PREPARING THEM PPG Industries Ohio, Inc. (US) 2016-10-19 EP claimed
EP-2801586-B1 Casting resin on a polythiourethane basis with high tensile strength and low specific weight BRUNO BOCK CHEM FAB GMBH & CO KG (DE) 2016-04-13 EP claimed
US-4791185-A POLYTHIOURETHANES BASED ON TRIMERCAPTO ALKYLENE ISOCYANURATES; HEAT RESISTANCE; WORKABILITY MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1988-12-13 US claimed
US-4748200-A Thermosetting resins and electrodeposition coating compositions containing the same TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1988-05-31 US claimed
US-4731415-A BIURETS FROM A,A,A*,A*-TETRAMETHYLXYLYLENE DIISOCYANATE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1988-03-15 US claimed
EP-0197543-A2 Polyisocyanates and resin compositions thereof Takeda Chemical Industries, Ltd. (JP) 1986-10-15 EP claimed
US-4617349-A PAINTS, COATINGS; QUICK-DRYING TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1986-10-14 US claimed
EP-0180873-A2 Urethane resin compositions Takeda Chemical Industries, Ltd. (JP) 1986-05-14 EP claimed
EP-0164491-A1 Process for the preparation of tertiary aralkyl urethanes and process for the preparation of isocyanates derived therefrom AMERICAN CYANAMID COMPANY (US) 1985-12-18 EP claimed
US-4523003-A Storage stable, one package, heat curable polyurea/urethane coating compositions and method of preparation AMERICAN CYANAMID COMPANY (US) 1985-06-11 US claimed
US-4439616-A THERMAL CRACKING, ACID CATALYST AMERICAN CYANAMID COMPANY (US) 1984-03-27 US claimed
EP-0101832-A1 Tertiary aralkyl urethanes and isocyanates derived therefrom AMERICAN CYANAMID COMPANY (US) 1984-03-07 EP claimed