Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 3/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 5/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 10/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312813 | 0.80 | ACVRL1 (0.43) | CFTRACVRL1RIPK1 | |
| SCHEMBL14327086 | 0.79 | RIPK1 (0.36) | RIPK1 | |
| SCHEMBL14327061 | 0.78 | ACVRL1 (0.36) | CFTRACVRL1RIPK1 | |
| SCHEMBL14531788 | 0.77 | ACVRL1 (0.43) | ACVRL1 | |
| SCHEMBL14312477 | 0.75 | ACVRL1 (0.40) | ACVRL1RIPK1 | |
| SCHEMBL14312618 | 0.74 | TYRO3 (0.48) | ACVRL1 | |
| SCHEMBL14327068 | 0.73 | RIPK1 (0.37) | ACVRL1RIPK1 | |
| SCHEMBL16496876 | 0.73 | PIK3CD (0.41) | ACVRL1RIPK1PIK3CD | |
| SCHEMBL14888089 | 0.73 | ACVRL1 (0.40) | ACVRL1PIK3CD | |
| SCHEMBL16496878 | 0.73 | RIPK1 (0.43) | ACVRL1RIPK1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056170-A2 | PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | BAYER HEALTHCARE AG (DE) | 2007-05-18 | — | — | WO | disclosed |