Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 18/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14327086 | 0.79 | RIPK1 (0.36) | RIPK1RETKDR | |
| SCHEMBL14312813 | 0.78 | ACVRL1 (0.43) | RIPK1RETKDRACVRL1 | |
| SCHEMBL14327061 | 0.76 | ACVRL1 (0.36) | RIPK1RETKDRACVRL1 | |
| SCHEMBL14899104 | 0.74 | ACVRL1 (0.40) | RIPK1ACVRL1 | |
| SCHEMBL14327071 | 0.73 | TYRO3 (0.44) | RIPK1ACVRL1 | |
| SCHEMBL14312500 | 0.73 | RIPK1 (0.41) | RIPK1ACVRL1 | |
| SCHEMBL14531789 | 0.73 | CFTR (0.34) | RIPK1ACVRL1 | |
| SCHEMBL16496878 | 0.73 | RIPK1 (0.43) | RIPK1ACVRL1 | |
| SCHEMBL14313357 | 0.73 | ACVRL1 (0.41) | RIPK1ACVRL1 | |
| SCHEMBL5077843 | 0.73 | ADORA3 (0.38) | RIPK1ACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945222-B1 | PYRROLO[2,1-F] [1,2,4]-TRIAZIN-4-YLAMINES AS IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | Bayer Pharma AG (DE) | 2012-12-26 | — | — | EP | disclosed |