Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | PDE2A | O00408 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16954266 | 0.85 | JAK2 (0.49) | JAK2JAK1TYK2PDE2AGAA | |
| SCHEMBL30740081 | 0.81 | JAK2 (0.57) | JAK2JAK1TYK2PDE2AGAA | |
| SCHEMBL1199588 | 0.81 | JAK2 (0.57) | JAK2JAK1TYK2PDE2AGAA | |
| SCHEMBL16950454 | 0.81 | JAK2 (0.43) | JAK2JAK1TYK2PDE2AGAA | |
| SCHEMBL28412823 | 0.80 | CES2 (0.41) | JAK2JAK1TYK2PDE2AGAA | |
| SCHEMBL17141748 | 0.79 | MEN1 (0.43) | GAACES2ALDH1A1MEN1KMT2A | |
| SCHEMBL16959559 | 0.79 | PDE2A (0.47) | JAK2JAK1TYK2PDE2AGAA | |
| SCHEMBL28415313 | 0.78 | CES2 (0.42) | PDE2AGAACES2SMN1; SMN2ALDH1A1 | |
| SCHEMBL28987801 | 0.78 | CES2 (0.42) | PDE2AGAACES2ALDH1A1KDM4E | |
| SCHEMBL18611579 | 0.77 | CES2 (0.44) | PDE2AGAACES2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007062308-A2 | HOMO- AND HETEROCYCLIC COMPOUNDS SUITABLE AS CETP INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-31 | — | — | WO | disclosed |