Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8938876 | 0.78 | LMNA (0.48) | CYP2D6CYP3A4MEN1KMT2ALMNA | |
| SCHEMBL4737348 | 0.78 | SLC22A12 (0.54) | CYP2D6LMNANR3C1EDNRAPDE4A | |
| SCHEMBL10059912 | 0.78 | SLC22A12 (0.54) | CYP2D6LMNANR3C1EDNRAPDE4A | |
| SCHEMBL7049165 | 0.75 | CA1 (0.45) | CYP2D6CYP3A4MEN1KMT2ALMNA | |
| SCHEMBL30954316 | 0.73 | EDNRA (0.67) | CYP2D6CYP3A4MEN1KMT2ALMNA | |
| SCHEMBL14510335 | 0.73 | EDNRA (0.42) | CYP2D6CYP3A4LMNANR3C1MAPK1 | |
| SCHEMBL13343329 | 0.71 | TUBB4A (0.61) | CYP3A4LMNANR3C1MAPTMAPK1 | |
| SCHEMBL13343328 | 0.69 | MAPT (0.49) | MEN1KMT2ALMNAL3MBTL1MAPT | |
| SCHEMBL18913562 | 0.68 | CYP2D6 (0.91) | CYP2D6CYP3A4NR3C1EDNRA | |
| SCHEMBL18913575 | 0.68 | CYP2D6 (0.91) | CYP2D6CYP3A4NR3C1EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070123491-A1 | Podophyllotoxin derivatives as igf-1r inhibitors | BIOVITRUM AB (SE) | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123491-A1 | Podophyllotoxin derivatives as igf-1r inhibitors | IGF1R, IGFBP1, INSR | CYP2D6 4524/4885CYP3A4 4629/4885MEN1 382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.