Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 9/20 | 0.61 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 2/20 | 0.50 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25369066 | 0.83 | PDE5A (0.64) | PDE5AMAOAPRKCZMAOBRIPK1 | |
| SCHEMBL14541148 | 0.81 | PDE5A (0.60) | PDE5ACA1CA2CA9MAOA | |
| SCHEMBL14540797 | 0.80 | PDE5A (0.60) | PDE5APRKCZMAOBRIPK1 | |
| SCHEMBL14540791 | 0.79 | RIPK1 (0.74) | PDE5APRKCZRIPK1 | |
| SCHEMBL14541221 | 0.79 | PDE5A (0.64) | PDE5APRKCZMEN1KMT2A | |
| SCHEMBL14540882 | 0.78 | CA1 (0.81) | CA1CA2CA9MAOAMEN1 | |
| SCHEMBL12494514 | 0.76 | PDE5A (1.00) | PDE5APRKCZ | |
| SCHEMBL14541083 | 0.75 | CA1 (0.74) | CA1CA2CA9MAOAMEN1 | |
| SCHEMBL14540883 | 0.75 | CA1 (0.78) | CA1CA2CA9MAOAMEN1 | |
| SCHEMBL15803417 | 0.74 | PRKCZ (0.76) | PDE5APRKCZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007038425-A2 | ANTI-VIRAL COMPOUINDS | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2007-04-05 | — | — | WO | disclosed |