SCHEMBL14548899

SCHEMBL14548899

N#Cc1ccc(N(N)Cc2ccc(Cl)c(OS(N)(=O)=O)c2)cc1

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 20/20 0.70
STS P08842 11/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3243049 0.83 CYP19A1 (1.00) CYP19A1STS
SCHEMBL14549047 0.78 CYP19A1 (0.56) CYP19A1STS
SCHEMBL3237817 0.74 CYP19A1 (1.00) CYP19A1STS
SCHEMBL5992113 0.73 CYP19A1 (0.54) CYP19A1STS
SCHEMBL5992333 0.72 LOXL2 (0.54) CYP19A1STS
SCHEMBL5990232 0.72 MAOA (0.50) CYP19A1
SCHEMBL5439291 0.71 CYP19A1 (0.79) CYP19A1STS
SCHEMBL14426837 0.70 CYP19A1 (1.00) CYP19A1STS
SCHEMBL2060377 0.70 CYP19A1 (1.00) CYP19A1STS
SCHEMBL6797851 0.69 CYP19A1 (0.67) CYP19A1STS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1446388-B1 1,2,4-TRIAZOLE DERIVATIVES CONTAINING A SULPHAMATE GROUP AS AROMATASE INHIBITORS STERIX LTD (GB) 2013-01-09 EP disclosed