Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | EDNRB | P24530 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.32 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.32 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14554230 | 0.87 | IDO1 (0.41) | MAPTIDO1KDM4E | |
| SCHEMBL16668782 | 0.74 | CMA1 (0.43) | MAPTCYP1A2MAPK1TP53POLB | |
| SCHEMBL16986622 | 0.74 | CYP1A2 (0.42) | MAPTCYP1A2MAPK1TP53POLB | |
| SCHEMBL4997975 | 0.71 | DYRK2 (0.52) | MAPTCYP1A2MAPK1TP53POLB | |
| SCHEMBL23752444 | 0.66 | MAPT (0.44) | MAPTCYP1A2MAPK1TP53POLB | |
| SCHEMBL25057548 | 0.65 | CMA1 (0.41) | MAPTCYP1A2MAPK1TP53POLB | |
| SCHEMBL9899738 | 0.64 | IDO1 (0.53) | MAPTIDO1KDM4E | |
| SCHEMBL23959112 | 0.64 | MAPT (0.50) | MAPTCYP1A2MAPK1TP53POLB | |
| SCHEMBL21067503 | 0.63 | TP53 (0.47) | MAPTCYP1A2MAPK1TP53POLB | |
| SCHEMBL31219834 | 0.62 | PGR (0.45) | MAPTTP53POLBNQO2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130012572-A1 | Compositions And Methods For Inhibiting Expression Of GSK-3 Genes | BANK OF AMERICA, N.A. | 2013-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130012572-A1 | Compositions And Methods For Inhibiting Expression Of GSK-3 Genes | GSK3A, GSK3B, GSKIP | MAPT 1963/4885CYP1A2 4789/4885MAPK1 3069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.