Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | S100A4 | P26447 | 1/20 | 0.38 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20925016 | 0.77 | ALDH1A1 (0.50) | MAPTGAAALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL12874910 | 0.75 | ALDH1A1 (0.34) | MAPTGAAALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL14558120 | 0.75 | ALDH1A1 (0.44) | MAPTGAAALDH1A1KMT2AGLO1 | |
| SCHEMBL7307524 | 0.75 | KMT2A (0.44) | MAPTALDH1A1KMT2AGLO1SMN1; SMN2 | |
| SCHEMBL16559365 | 0.75 | MAPT (0.61) | MAPTGAAALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL12046659 | 0.73 | KDM4E (0.50) | MAPTGAAALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL7320868 | 0.70 | MAPT (0.64) | MAPTGAAALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7320861 | 0.70 | MAPT (0.64) | MAPTGAAALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5656396 | 0.69 | MAPT (0.59) | MAPTGAAALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL10528568 | 0.68 | ALDH1A1 (0.58) | MAPTGAAALDH1A1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186743-B2 | Substituted pyrazolyl compounds for the treatment of inflammation | PHARMACIA CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |