Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 8/20 | 0.65 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.65 |
| ▸ | TSHR | P16473 | 3/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9667084 | 0.81 | MTNR1A (0.65) | MTNR1AMTNR1BCYP1A2CYP2C19TSHR | |
| SCHEMBL6947949 | 0.81 | MTNR1A (0.64) | MTNR1AMTNR1BCYP1A2CYP2C19TSHR | |
| SCHEMBL24098945 | 0.80 | MTNR1A (0.72) | MTNR1AMTNR1BCYP1A2CYP2C19TSHR | |
| Luzindole SCHEMBL4869000 | 0.79 | MTNR1A (1.00) | MTNR1AMTNR1BCYP1A2CYP2C19TSHR | |
| SCHEMBL14560403 | 0.78 | RAD52 (0.48) | MTNR1AMTNR1BCYP1A2CYP2C19TSHR | |
| SCHEMBL28804680 | 0.78 | RAB9A (0.54) | TSHRHPGDALOX15PABPC1ALDH1A1 | |
| SCHEMBL14560404 | 0.77 | EGFR (0.62) | ALDH1A1MAPTKDM4E | |
| SCHEMBL14560402 | 0.77 | KDM4E (0.64) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL9401161 | 0.76 | MTNR1A (0.84) | MTNR1AMTNR1BCYP1A2CYP2C19TSHR | |
| SCHEMBL14560406 | 0.76 | EGFR (0.66) | CYP3A4ALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189721-B2 | Bicyclic protein kinase inhibitors | SUGEN INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-7189721-B2 | Bicyclic protein kinase inhibitors | SUGEN INC. (US) | 2007-03-13 | — | — | US | disclosed |