Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR1F | P30939 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27817269 | 0.82 | ALDH1A1 (0.60) | RAD52HTR6MAPTTSHRHTR1A | |
| SCHEMBL14560412 | 0.78 | MTNR1A (0.65) | MAPTTSHRMEN1CYP1A2CYP3A4 | |
| SCHEMBL28804680 | 0.78 | RAB9A (0.54) | HTR6MAPTTSHRHKDC1NPSR1 | |
| SCHEMBL14560402 | 0.77 | KDM4E (0.64) | MAPTHKDC1NPSR1MEN1KMT2A | |
| SCHEMBL14560404 | 0.77 | EGFR (0.62) | HTR6MAPTHKDC1NPSR1ALDH1A1 | |
| SCHEMBL13962342 | 0.76 | SIRT1 (0.48) | RAD52HTR6MAPTTSHRMEN1 | |
| SCHEMBL14560406 | 0.76 | EGFR (0.66) | HTR6MAPTHKDC1NPSR1HTR1A | |
| SCHEMBL14560419 | 0.76 | KDM4E (0.62) | HTR6MAPTTSHRHKDC1NPSR1 | |
| SCHEMBL28204517 | 0.75 | MAPT (0.41) | HTR6MAPTTSHRHKDC1NPSR1 | |
| SCHEMBL7380422 | 0.75 | HTT (0.51) | MAPTTSHRHKDC1NPSR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189721-B2 | Bicyclic protein kinase inhibitors | SUGEN INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-7189721-B2 | Bicyclic protein kinase inhibitors | SUGEN INC. (US) | 2007-03-13 | — | — | US | disclosed |