Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 6/20 | 0.46 |
| ▸ | CD74 | P04233 | 3/20 | 0.46 |
| ▸ | MET | P08581 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3633760 | 0.89 | ACHE (0.43) | MIFCD74 | |
| SCHEMBL2548549 | 0.88 | MET (0.42) | MIFCD74METPOLBMEN1 | |
| SCHEMBL12241020 | 0.86 | POLB (0.42) | MIFCD74METPOLBMEN1 | |
| SCHEMBL3632213 | 0.85 | MET (0.50) | MIFCD74METPOLBMEN1 | |
| SCHEMBL3633761 | 0.84 | MIF (0.52) | MIFCD74POLBMEN1KMT2A | |
| SCHEMBL2544326 | 0.83 | POLB (0.46) | MIFCD74METPOLB | |
| SCHEMBL3631935 | 0.77 | MET (0.50) | MIFCD74METPOLBMEN1 | |
| SCHEMBL12241153 | 0.75 | MET (0.61) | MIFCD74METPOLBTNIK | |
| SCHEMBL3631378 | 0.75 | ACHE (0.48) | MIFCD74MET | |
| SCHEMBL12241036 | 0.74 | POLB (0.46) | MIFCD74METPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150551-B1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2013-01-16 | — | — | EP | disclosed |