Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 8/20 | 0.52 |
| ▸ | CD74 | P04233 | 5/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | CBX7 | O95931 | 1/20 | 0.41 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.41 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.41 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2546995 | 0.86 | MAPT (0.49) | MIFCD74POLBMEN1KMT2A | |
| SCHEMBL14563289 | 0.84 | MIF (0.46) | MIFCD74POLBMEN1KMT2A | |
| SCHEMBL3632213 | 0.76 | MET (0.50) | MIFCD74POLBMEN1KMT2A | |
| SCHEMBL3633760 | 0.75 | ACHE (0.43) | MIFCD74 | |
| SCHEMBL3627242 | 0.75 | MIF (0.53) | MIFCD74POLBMEN1KMT2A | |
| SCHEMBL3665095 | 0.72 | MIF (0.51) | MIFCD74POLBMEN1KMT2A | |
| SCHEMBL3629237 | 0.72 | TNIK (0.52) | MIFCD74POLBMEN1KMT2A | |
| SCHEMBL3633704 | 0.72 | MIF (0.50) | MIFCD74POLBMEN1KMT2A | |
| SCHEMBL2548549 | 0.71 | MET (0.42) | MIFCD74POLBMEN1KMT2A | |
| SCHEMBL29566319 | 0.70 | MIF (0.84) | MIFCD74POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150551-B1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2013-01-16 | — | — | EP | disclosed |
| EP-2150551-A1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | Merck Patent GmbH (DE) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008148449-A1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2008-12-11 | — | — | WO | disclosed |