Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 10/20 | 0.56 |
| ▸ | MMP13 | P45452 | 6/20 | 0.56 |
| ▸ | MMP1 | P03956 | 4/20 | 0.56 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.56 |
| ▸ | MMP14 | P50281 | 2/20 | 0.56 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.56 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.56 |
| ▸ | MMP9 | P14780 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 6/20 | 0.46 |
| ▸ | CA9 | Q16790 | 6/20 | 0.46 |
| ▸ | CA12 | O43570 | 5/20 | 0.46 |
| ▸ | CA1 | P00915 | 5/20 | 0.46 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 2/20 | 0.44 |
| ▸ | TARS1 | P26639 | 1/20 | 0.44 |
| ▸ | MMP7 | P09237 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14378294 | 0.89 | CASP1 (0.48) | MMP2MMP13MMP1MMP14MEP1B | |
| SCHEMBL14565748 | 0.89 | ALDH1A1 (0.46) | MMP2MMP13MMP1ADAMTS4MMP14 | |
| SCHEMBL5445424 | 0.81 | MMP2 (0.61) | MMP2MMP13MMP1ADAMTS4MMP14 | |
| SCHEMBL5445420 | 0.81 | MMP2 (0.61) | MMP2MMP13MMP1ADAMTS4MMP14 | |
| SCHEMBL7247467 | 0.76 | MMP2 (0.72) | MMP2MMP13MMP1ADAMTS4MMP14 | |
| SCHEMBL6557782 | 0.76 | MMP2 (0.64) | MMP2MMP13MMP1ADAMTS4MMP14 | |
| SCHEMBL5899447 | 0.72 | MMP2 (0.70) | MMP2MMP13MMP1ADAMTS4MMP14 | |
| SCHEMBL6557780 | 0.71 | MMP2 (0.61) | MMP2MMP13MMP1ADAMTS4MMP14 | |
| SCHEMBL5445650 | 0.70 | ALDH1A1 (0.48) | MMP2MMP13MMP1ADAMTS4MMP14 | |
| SCHEMBL5445643 | 0.70 | ALDH1A1 (0.51) | MMP2MMP13MMP1ADAMTS4MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196099-B2 | Compounds and compositions as cathepsin inhibitors | AVENTIS PHARMACEUTICALS INC. (US) | 2007-03-27 | — | — | US | disclosed |