Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 11/20 | 0.64 |
| ▸ | MMP1 | P03956 | 7/20 | 0.64 |
| ▸ | ADAMTS4 | O75173 | 5/20 | 0.64 |
| ▸ | MMP13 | P45452 | 5/20 | 0.64 |
| ▸ | MMP14 | P50281 | 4/20 | 0.64 |
| ▸ | ADAMTS5 | Q9UNA0 | 4/20 | 0.64 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.64 |
| ▸ | CTSK | P43235 | 2/20 | 0.53 |
| ▸ | CTSS | P25774 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 6/20 | 0.51 |
| ▸ | CA9 | Q16790 | 6/20 | 0.51 |
| ▸ | CA12 | O43570 | 5/20 | 0.51 |
| ▸ | CA1 | P00915 | 5/20 | 0.51 |
| ▸ | MMP9 | P14780 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6557790 | 0.87 | MMP1 (0.50) | MMP2MMP1ADAMTS4MMP13MMP14 | |
| SCHEMBL8048075 | 0.83 | MMP2 (0.65) | MMP2MMP1ADAMTS4MMP13MMP14 | |
| SCHEMBL6557780 | 0.82 | MMP2 (0.61) | MMP2MMP1ADAMTS4MMP13MMP14 | |
| SCHEMBL7247467 | 0.82 | MMP2 (0.72) | MMP2MMP1ADAMTS4MMP13MMP14 | |
| SCHEMBL7163404 | 0.81 | MMP2 (0.62) | MMP2MMP1ADAMTS4MMP13MMP14 | |
| SCHEMBL5899447 | 0.78 | MMP2 (0.70) | MMP2MMP1ADAMTS4MMP13MMP14 | |
| SCHEMBL5445424 | 0.77 | MMP2 (0.61) | MMP2MMP1ADAMTS4MMP13MMP14 | |
| SCHEMBL5445420 | 0.77 | MMP2 (0.61) | MMP2MMP1ADAMTS4MMP13MMP14 | |
| SCHEMBL7168984 | 0.77 | KAT6A (0.58) | MMP2MMP1ADAMTS4MMP13MMP14 | |
| SCHEMBL14565746 | 0.76 | MMP2 (0.56) | MMP2MMP1ADAMTS4MMP13MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436255-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS | Aventis Pharmaceuticals, Inc. (US) | 2004-07-14 | — | — | EP | claimed |
| WO-2003024924-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2003-03-27 | — | — | WO | claimed |