Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 16/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5244202 | 0.80 | ESR1 (0.48) | ESR1ESR2HDAC3HDAC1HDAC2 | |
| SCHEMBL5242224 | 0.79 | ESR1 (0.47) | ESR1ESR2HDAC3HDAC1HDAC2 | |
| SCHEMBL32664256 | 0.71 | GPR35 (0.44) | ESR1 | |
| SCHEMBL24682202 | 0.66 | PDK1 (0.45) | ESR1ESR2 | |
| SCHEMBL29799815 | 0.66 | PDK1 (0.45) | ESR1ESR2 | |
| SCHEMBL29121145 | 0.66 | HDAC3 (0.45) | HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL1616936 | 0.65 | ESR1 (0.51) | ESR1ESR2HDAC3HDAC1HDAC2 | |
| SCHEMBL5241179 | 0.65 | ESR1 (0.48) | ESR1ESR2 | |
| SCHEMBL5241720 | 0.63 | RAB9A (0.50) | ESR1ESR2HDAC3HDAC1HDAC2 | |
| SCHEMBL29980342 | 0.63 | HTT (0.44) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007026221-A2 | IMPROVED METHODS FOR PREPARING BENZOFUSED HETEROARYL AMIDE DERIVATIVES OF THIENOPYRIDINES | PFIZER INC. (US) | 2007-03-08 | — | — | WO | disclosed |