Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TACR2 | P21452 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12517550 | 0.82 | TSHR (0.47) | EPHX2LMNAPOLB | |
| SCHEMBL18343293 | 0.81 | ALDH1A1 (0.64) | SMN1; SMN2LMNAPOLB | |
| SCHEMBL27332191 | 0.81 | EPHX1 (0.47) | SMN1; SMN2MAPTEPHX2PDGFRBKDR | |
| SCHEMBL3323121 | 0.79 | MAPT (0.44) | SMN1; SMN2MAPTCYP3A4CYP2D6CYP2C19 | |
| SCHEMBL16581991 | 0.79 | PDGFRB (0.44) | SMN1; SMN2MAPTPDGFRBKDRLMNA | |
| SCHEMBL15639503 | 0.78 | NPC1 (0.60) | SMN1; SMN2MAPTCYP2C19TP53 | |
| SCHEMBL488233 | 0.78 | MEN1 (0.40) | EPHX2CYP3A4LMNAPOLB | |
| SCHEMBL3322268 | 0.77 | LPL (0.45) | SMN1; SMN2MAPTPDGFRBKDR | |
| SCHEMBL3321460 | 0.76 | PRMT5 (0.46) | EPHX2CYP3A4CYP2C19LMNA | |
| SCHEMBL3322078 | 0.74 | LIPG (0.61) | SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |
| US-7157460-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-01-02 | — | — | US | disclosed |
| US-7157460-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-01-02 | — | — | US | disclosed |