Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL488274 | 0.91 | SRC (0.44) | MAP4K4ALDH1A1CA12CA1CA2 | |
| SCHEMBL488893 | 0.90 | SRC (0.44) | MEN1KMT2AMAP4K4ALDH1A1CA12 | |
| SCHEMBL488839 | 0.87 | CA1 (0.52) | MEN1KMT2AEPHX2TSHRMAP4K4 | |
| SCHEMBL488765 | 0.87 | KDM1A (0.40) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL488629 | 0.86 | SMN1; SMN2 (0.38) | EPHX2CA12CA1CA2CA3 | |
| SCHEMBL17896410 | 0.84 | MAP4K4 (0.48) | MEN1KMT2AEPHX2MAP4K4CYP3A4 | |
| SCHEMBL488672 | 0.84 | ROCK1 (0.36) | CA12CA1CA2CA3CA4 | |
| SCHEMBL488764 | 0.83 | CYP2D6 (0.38) | CA12CA1CA2CA3CA4 | |
| SCHEMBL2508131 | 0.81 | LPL (0.48) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL16238072 | 0.79 | LPL (0.48) | CA12CA1CA2CA3CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106197-B2 | Aminoheteroaryl compounds as protein kinase inhibitors | PFIZER INC. (US) | 2012-01-31 | — | — | US | disclosed |