Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | SGK1 | O00141 | 1/20 | 0.42 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 2/20 | 0.40 |
| ▸ | BECN1 | Q14457 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31396449 | 0.87 | PIK3CA (0.45) | KMT2APIK3CAPIK3CBPIK3CGMEN1 | |
| SCHEMBL17203013 | 0.74 | KMT2A (0.55) | KMT2AMEN1ATMMAPTGAA | |
| SCHEMBL14573284 | 0.73 | MAPT (0.39) | KMT2AMEN1PORCNBCL2BECN1 | |
| SCHEMBL3573967 | 0.73 | MAPT (0.66) | KMT2AMEN1ATMMAPTGAA | |
| SCHEMBL1492829 | 0.72 | PORCN (0.73) | KMT2AMEN1SGK1PORCNATM | |
| SCHEMBL4631425 | 0.72 | ALDH1A1 (0.56) | KMT2AMEN1SGK1PORCNATM | |
| SCHEMBL4516346 | 0.72 | SYK (0.36) | KMT2AMEN1MAPTGAANPC1 | |
| SCHEMBL4530760 | 0.71 | PIK3CA (0.48) | KMT2APIK3CAPIK3CBPIK3CGMEN1 | |
| SCHEMBL29460423 | 0.70 | MMP1 (0.51) | KMT2AMEN1ATMMAPTMMP1 | |
| SCHEMBL4535524 | 0.70 | ATM (0.39) | KMT2AMEN1SGK1ATMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211919-B2 | Amide derivatives as rock inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-07-03 | — | — | US | disclosed |
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ROCK1, ROCK2, RHOA | KMT2A 735/4885PIK3CA 398/4885PIK3CB 493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.