Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 14/20 | 0.57 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28203089 | 0.98 | TLR8 (0.58) | TLR8TLR7ATMSMN1; SMN2LMNA | |
| SCHEMBL22498767 | 0.98 | TLR8 (0.58) | TLR8TLR7ATMSMN1; SMN2LMNA | |
| SCHEMBL29377718 | 0.98 | TLR8 (0.58) | TLR8TLR7ATMSMN1; SMN2LMNA | |
| SCHEMBL28504818 | 0.90 | TLR8 (0.51) | TLR8TLR7ATMSMN1; SMN2LMNA | |
| SCHEMBL28229720 | 0.88 | KDM4E (0.55) | TLR8TLR7DCPS | |
| SCHEMBL28510573 | 0.88 | TLR8 (0.54) | TLR8TLR7LMNATSHR | |
| SCHEMBL28508187 | 0.87 | TLR8 (0.48) | TLR8TLR7LMNATSHR | |
| SCHEMBL28503550 | 0.85 | TLR8 (0.54) | TLR8TLR7LMNA | |
| SCHEMBL28906706 | 0.82 | TLR8 (0.54) | TLR8TLR7LMNA | |
| SCHEMBL13585880 | 0.82 | TLR8 (0.48) | TLR8TLR7ATMSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112457260-B | N-heterocyclic aryl quinazoline-4-amine compound and preparation method thereof | 江苏食品药品职业技术学院 | 2023-01-17 | — | — | CN | claimed |
| CN-112457260-A | N-heterocyclic aryl quinazoline-4-amine compound and preparation method thereof | 江苏食品药品职业技术学院 | 2021-03-09 | — | — | CN | claimed |
| CN-112457260-B | N-heterocyclic aryl quinazoline-4-amine compound and preparation method thereof | 江苏食品药品职业技术学院 | 2023-01-17 | — | — | CN | disclosed |
| CN-112457260-B | N-heterocyclic aryl quinazoline-4-amine compound and preparation method thereof | 江苏食品药品职业技术学院 | 2023-01-17 | — | — | CN | disclosed |
| CN-112457260-B | N-heterocyclic aryl quinazoline-4-amine compound and preparation method thereof | 江苏食品药品职业技术学院 | 2023-01-17 | — | — | CN | disclosed |
| CN-114835683-A | Quinazoline-4, 6-diamine compound containing morpholinyl aromatic heterocycle and preparation method thereof | 江苏食品药品职业技术学院 | 2022-08-02 | — | — | CN | disclosed |
| CN-112457260-A | N-heterocyclic aryl quinazoline-4-amine compound and preparation method thereof | 江苏食品药品职业技术学院 | 2021-03-09 | — | — | CN | disclosed |
| CN-112457260-A | N-heterocyclic aryl quinazoline-4-amine compound and preparation method thereof | 江苏食品药品职业技术学院 | 2021-03-09 | — | — | CN | disclosed |
| CN-112457260-A | N-heterocyclic aryl quinazoline-4-amine compound and preparation method thereof | 江苏食品药品职业技术学院 | 2021-03-09 | — | — | CN | disclosed |
| US-8796180-B2 | Aminoquinazoline compounds for combating invertebrate pests | BASF SE (DE) | 2014-08-05 | — | — | US | disclosed |
| EP-2480537-A1 | AMINOQUINAZOLINE COMPOUNDS FOR COMBATING INVERTEBRATE PESTS | BASF SE (DE) | 2012-08-01 | — | — | EP | disclosed |
| EP-1654236-A1 | NAPHTHYLENE DERIVATIVES AS CYTOCHROME P450 INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2006-05-10 | — | — | EP | disclosed |
| CN-1242993-C | Heterocycle derivatives and drugs | NIPPON SHINYAKU CO LTD (JP) | 2006-02-22 | — | — | CN | disclosed |
| US-20060009645-A1 | Naphthylene derivatives as cytochrome P450 inhibitors | OSI PHARMACEUTICALS, INC. | 2006-01-12 | — | — | US | disclosed |
| CN-1597671-A | Quinazoline deriative and preparation method and bioactivity | UNIV GUIZHOU (CN) | 2005-03-23 | — | — | CN | disclosed |
| WO-2005007631-A1 | NAPHTHYLENE DERIVATIVES AS CYTOCHROME P450 INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2005-01-27 | — | — | WO | disclosed |
| US-6613772-B1 | Drugs such as 2-(p-chlorophenyl-4-(4-hydroxybutyl)amino-6,7,8 -trimethoxyquinazoline used for activation of guanylate cyclase and modulation of cyclic guanosine monophosphate | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-09-02 | — | — | US | disclosed |
| CN-1422255-A | Heterocycle derivatives and drugs | NIPPON SHINYAKU CO LTD (JP) | 2003-06-04 | — | — | CN | disclosed |
| EP-1040101-A1 | SUBSTITUTED 2-ARYL-4-AMINO-CHINAZOLINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | Aventis Pharma Deutschland GmbH (DE) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999032460-A1 | SUBSTITUTED 2-ARYL-4-AMINO-CHINAZOLINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060009645-A1 | Naphthylene derivatives as cytochrome P450 inhibitors | CYP1A1, CYP1A2, RARA | TLR8 3958/4885TLR7 2595/4885ATM 4657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.