Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 14/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.49 |
| ▸ | HPN | P05981 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14586319 | 0.80 | VCAM1 (0.67) | VCAM1ALOX15HPNMAPTSIRT5 | |
| SCHEMBL12042599 | 0.80 | ALOX15 (0.60) | VCAM1ALOX15HPNMAPTSIRT5 | |
| SCHEMBL14586314 | 0.80 | VCAM1 (0.53) | VCAM1ALOX15HPNMAPTSIRT5 | |
| Elsibucol SCHEMBL6002307 | 0.79 | VCAM1 (0.73) | VCAM1ALOX15HPNMAPTSIRT5 | |
| SCHEMBL13609378 | 0.79 | VCAM1 (0.60) | VCAM1ALOX15HPNMAPTSIRT5 | |
| SCHEMBL8243913 | 0.79 | ALOX15 (0.58) | VCAM1ALOX15HPNMAPTSIRT5 | |
| SCHEMBL12042598 | 0.79 | ALOX15 (0.62) | VCAM1ALOX15HPNMAPTSIRT5 | |
| SCHEMBL6000617 | 0.78 | VCAM1 (0.73) | VCAM1ALOX15HPNMAPTSIRT5 | |
| SCHEMBL14037559 | 0.78 | VCAM1 (0.70) | VCAM1ALOX15HPNMAPTSIRT5 | |
| SCHEMBL15437699 | 0.78 | GAA (0.59) | ALOX15MAPTTSHRALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7183317-B2 | Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality | ATHEROGENICS, INC. (US) | 2007-02-27 | — | — | US | disclosed |
| US-7183317-B2 | Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality | ATHEROGENICS, INC. (US) | 2007-02-27 | — | — | US | disclosed |