Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.39 |
| ▸ | ATP2A3 | Q93084 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 4/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | TYR | P14679 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8989499 | 0.79 | L3MBTL1 (0.41) | ALDH1A1CYP1A2CYP2C19HTTHSD17B10 | |
| SCHEMBL10264977 | 0.78 | HTT (0.33) | ALDH1A1SMN1; SMN2ALOX15KDM4ECYP1A2 | |
| SCHEMBL22949453 | 0.77 | L3MBTL1 (0.33) | ALDH1A1SMN1; SMN2ALOX15KDM4ECYP1A2 | |
| SCHEMBL13145646 | 0.77 | L3MBTL1 (0.33) | ALDH1A1SMN1; SMN2ALOX15KDM4ECYP1A2 | |
| SCHEMBL7749594 | 0.77 | HSP90AA1 (0.42) | ALDH1A1SMN1; SMN2ALOX15KDM4ECYP1A2 | |
| SCHEMBL25950813 | 0.77 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2ALOX15KDM4ECYP1A2 | |
| SCHEMBL23478377 | 0.75 | IDO1 (0.39) | CYP1A2HTTHSD17B10PLAUGLA | |
| SCHEMBL6370666 | 0.75 | L3MBTL1 (0.35) | ALDH1A1SMN1; SMN2ALOX15KDM4ECYP1A2 | |
| SCHEMBL25950824 | 0.75 | LMNA (0.34) | ALDH1A1SMN1; SMN2ALOX15KDM4ECYP1A2 | |
| SCHEMBL12401753 | 0.72 | LMNA (0.43) | ALDH1A1SMN1; SMN2ALOX15KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230271939-A1 | 4-ETHYNYLPYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS | IP2IPO INNOVATIONS LIMITED (GB) | 2023-08-31 | — | — | US | disclosed |
| US-20070027321-A1 | Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 | MERCK SHARP & DOHME CORP. | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230271939-A1 | 4-ETHYNYLPYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS | EIF2AK4, GCN1, EIF5B | ALDH1A1 2504/4885SMN1; SMN2 2267/4885ALOX15 2153/4885 |
| US-20070027321-A1 | Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 | GRM5, GRIK5, GRM1 | ALDH1A1 2178/4885SMN1; SMN2 2910/4885ALOX15 707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.