Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 6/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6554427 | 0.85 | EPHX2 (0.55) | POLBALDH1A1KDM4EL3MBTL1MAPT | |
| Hydrochloric Acid SCHEMBL5168514 | 0.84 | EPHX2 (0.54) | POLBALDH1A1KDM4EL3MBTL1MAPT | |
| SCHEMBL14540063 | 0.84 | HTR3A (0.48) | CHRM3CHRM2CHRM1KMT2AALDH1A1 | |
| SCHEMBL14540182 | 0.78 | FPR1 (0.45) | CHRM3CHRM2CHRM1 | |
| SCHEMBL14540137 | 0.77 | HCRTR1 (0.47) | CHRM3CHRM2CHRM1POLB | |
| SCHEMBL14539956 | 0.76 | DRD2 (0.45) | CHRM3CHRM2CHRM1 | |
| SCHEMBL6556410 | 0.75 | CHRM2 (0.44) | CHRM3CHRM2CHRM1KMT2AALDH1A1 | |
| SCHEMBL14540002 | 0.74 | KDM1A (0.42) | CHRM3CHRM2CHRM1 | |
| SCHEMBL30965967 | 0.74 | CHRNA7 (0.55) | CHRM3CHRM2CHRM1KMT2APOLB | |
| SCHEMBL13399620 | 0.73 | CHRM3 (0.66) | CHRM3CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2480228-A1 | USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS | Novartis AG (CH) | 2012-08-01 | — | — | EP | disclosed |
| WO-2011036167-A1 | USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS | NOVARTIS AG (CH) | 2011-03-31 | — | — | WO | disclosed |