SCHEMBL14596143

SCHEMBL14596143

NCc1cccc2c(-c3c(P(=O)(c4ccccc4)c4ccccc4)ccc4c(CN)cccc34)c(P(=O)(c3ccccc3)c3ccccc3)ccc12

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.35
MEN1 O00255 1/20 0.35
NPSR1 Q6W5P4 2/20 0.34
POLB P06746 2/20 0.34
ALDH1A1 P00352 1/20 0.34
HTT P42858 1/20 0.34
LOXL2 Q9Y4K0 2/20 0.33
DPP4 P27487 1/20 0.33
TOP1 P11387 1/20 0.32
ACP3 P15309 1/20 0.32
LMNA P02545 1/20 0.32
PNMT P11086 1/20 0.31
CYP2A6 P11509 1/20 0.30
APOBEC3A P31941 1/20 0.30
CASP6 P55212 1/20 0.30
CTDSP1 Q9GZU7 1/20 0.30
APOBEC3G Q9HC16 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13536496 0.76 NPSR1 (0.36) KMT2AMEN1NPSR1POLBALDH1A1
SCHEMBL14596137 0.76 KMT2A (0.40) KMT2AMEN1NPSR1POLBALDH1A1
SCHEMBL30401760 0.76 MEN1 (0.41) KMT2AMEN1NPSR1POLBALDH1A1
SCHEMBL1305767 0.73 NPSR1 (0.37) KMT2AMEN1NPSR1POLBALDH1A1
SCHEMBL14596131 0.73 CA1 (0.39) KMT2AMEN1NPSR1POLBALDH1A1
SCHEMBL132989 0.72 WDR5 (0.44) NPSR1POLBALDH1A1HTTLMNA
SCHEMBL29382484 0.72 WDR5 (0.44) NPSR1POLBALDH1A1HTTLMNA
SCHEMBL14020795 0.70 NPSR1 (0.52) KMT2AMEN1NPSR1POLBALDH1A1
SCHEMBL132985 0.70 NPSR1 (0.44) KMT2AMEN1NPSR1POLBALDH1A1
SCHEMBL29463705 0.70 PNMT (0.52) ALDH1A1LOXL2DPP4PNMTCYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070010695-A1 Diphosphines, preparation and uses thereof CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2007-01-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070010695-A1 Diphosphines, preparation and uses thereof MPI, ITPA, DCPS KMT2A 3070/4885MEN1 2694/4885NPSR1 3603/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.