Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 2/20 | 0.46 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19364184 | 0.89 | P2RX3 (0.42) | P2RX3P2RX2POLBGAAGFER | |
| SCHEMBL14566650 | 0.87 | TAAR1 (0.44) | POLBGAASMN1; SMN2KDM4ELMNA | |
| SCHEMBL14566485 | 0.85 | ALDH1A1 (0.36) | P2RX3P2RX2POLBGAAGFER | |
| SCHEMBL20183061 | 0.83 | ALOX15 (0.40) | P2RX3P2RX2POLBGAAGFER | |
| SCHEMBL1493906 | 0.83 | P2RX3 (0.47) | P2RX3P2RX2POLBGAAGFER | |
| SCHEMBL2485209 | 0.83 | P2RX3 (0.50) | P2RX3P2RX2CYP1A2CYP2D6HTR2C | |
| SCHEMBL1494087 | 0.83 | P2RX3 (0.47) | P2RX3P2RX2TAAR1 | |
| SCHEMBL12832328 | 0.80 | P2RX3 (0.34) | P2RX3P2RX2POLBGAAGFER | |
| Thymoquinol Dimethylether SCHEMBL12613923 | 0.79 | POLB (0.66) | P2RX3P2RX2POLBGAAGFER | |
| SCHEMBL13087352 | 0.79 | LMNA (0.43) | P2RX3P2RX2POLBGAAGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007025898-A1 | PROCESS FOR SYNTHESIS OF ARYLOXY DIAMINOPYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |