Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 16/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 8/20 | 0.41 |
| ▸ | PGR | P06401 | 6/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1460085 | 0.73 | KIF11 (0.42) | NR3C1KIF11ARPGRPTGS2 | |
| SCHEMBL28160376 | 0.70 | PTGS2 (0.54) | KIF11PTGS2 | |
| SCHEMBL585873 | 0.65 | KIF11 (0.60) | KIF11ARPTGS2 | |
| SCHEMBL28111372 | 0.64 | PTGS2 (0.58) | PTGS2 | |
| SCHEMBL18751892 | 0.63 | PTGS2 (0.42) | NR3C1ARPGRPTGS2 | |
| SCHEMBL1460151 | 0.63 | CYP11B1 (0.36) | NR3C1PGR | |
| SCHEMBL4011934 | 0.63 | NR1H2 (0.83) | — | |
| SCHEMBL17394027 | 0.63 | GLA (0.56) | KIF11PTGS2 | |
| SCHEMBL1460084 | 0.63 | NR3C1 (0.42) | NR3C1KIF11ARPGR | |
| SCHEMBL4013753 | 0.62 | NR1H2 (0.80) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011036130-A1 | INDOLE DERIVATIVES AS CRAC MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-31 | — | — | WO | disclosed |