SCHEMBL14601526

SCHEMBL14601526

O=C(Nc1ccc(OCCO)cc1O)c1ccc(C(=O)Nc2ccc(OCCO)cc2O)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLK1 P53350 3/20 0.47
MAPT P10636 5/20 0.47
F10 P00742 1/20 0.47
MCHR1 Q99705 1/20 0.46
HPGD P15428 2/20 0.46
KDM4E B2RXH2 1/20 0.46
ALDH1A1 P00352 1/20 0.46
HSD17B10 Q99714 1/20 0.45
GAA P10253 1/20 0.45
HSD17B13 Q7Z5P4 1/20 0.45
KMT2A Q03164 2/20 0.44
TP53 P04637 1/20 0.44
RXFP1 Q9HBX9 1/20 0.44
LMNA P02545 1/20 0.44
MAPK1 P28482 1/20 0.44
NPC1 O15118 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2C9 P11712 1/20 0.44
RAB9A P51151 1/20 0.44
HDAC1 Q13547 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28455353 0.87 HDAC1 (0.54) PLK1MAPTF10GAAKMT2A
SCHEMBL28460754 0.83 MCHR1 (0.61) PLK1MAPTF10MCHR1HPGD
SCHEMBL14679064 0.77 MEN1 (0.64) MAPTHPGDKDM4EALDH1A1GAA
SCHEMBL7806605 0.77 NPC1 (0.58) PLK1MAPTF10HPGDALDH1A1
SCHEMBL5180990 0.76 MAPT (0.64) MAPTMCHR1HPGDKDM4EALDH1A1
SCHEMBL22192224 0.76 MAPT (0.64) MAPTMCHR1HPGDKDM4EALDH1A1
SCHEMBL5182631 0.75 THRB (0.64) MAPTALDH1A1KMT2ATP53LMNA
SCHEMBL12464788 0.74 RAB9A (0.65) MAPTKDM4EALDH1A1HSD17B10KMT2A
SCHEMBL8770602 0.73 GAA (0.64) MAPTMCHR1KDM4EALDH1A1HSD17B10
SCHEMBL10621312 0.73 GAA (0.59) MAPTHPGDKDM4EALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070020418-A1 Acetaldehyde scavenging by addition of active scavengers to bottle closures HOWELL EARL E JR 2007-01-25 US disclosed
US-20070020418-A1 Acetaldehyde scavenging by addition of active scavengers to bottle closures HOWELL EARL E JR 2007-01-25 US disclosed
EP-1739026-A1 Acetaldehyde scavenging by addition of active scavengers to bottle closures Eastman Chemical Company (US) 2007-01-03 EP disclosed