Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.49 |
| ▸ | HPGD | P15428 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.49 |
| ▸ | GFER | P55789 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10704376 | 0.77 | ALDH1A1 (0.61) | KDM4EMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL30373749 | 0.77 | KDM4E (0.53) | KDM4EMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL5568381 | 0.77 | KDM4E (0.53) | KDM4EMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL9572914 | 0.76 | KDM4E (0.50) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL6215070 | 0.76 | KDM4E (0.47) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL29150402 | 0.75 | MAP2 (0.51) | KDM4EMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL28424735 | 0.75 | KDM4E (0.49) | KDM4EMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL23206861 | 0.74 | KDM4E (0.52) | KDM4EMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL16433366 | 0.74 | KDM4E (0.66) | KDM4EMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL5567717 | 0.73 | MEN1 (0.50) | KDM4EMEN1KMT2APOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169925-B2 | Indole derivatives as interleukin-4 gene expression inhibitors | AVENTIS PHARMACEUTICALS INC. (US) | 2007-01-30 | — | — | US | disclosed |