SCHEMBL1460281

SCHEMBL1460281

CN1CCN(N2CCCCC2)CC1

nearest known ligand 0.56

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
HRH4 Q9H3N8 2/20 0.31
LMNA P02545 1/20 0.31
PHGDH O43175 1/20 0.31
MGLL Q99685 1/20 0.31
HRH3 Q9Y5N1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8440512 0.97 TDP1 (0.35) CYP1A2TDP1HRH4PHGDHMGLL
SCHEMBL10780186 0.94 LMNA (0.38) CYP1A2TDP1LMNA
SCHEMBL4831157 0.90 TDP1 (0.35) CYP1A2TDP1LMNAPHGDHMGLL
SCHEMBL15217805 0.86 CYP1A2 (0.40) CYP1A2TDP1PHGDHMGLL
SCHEMBL16015284 0.82 LMNA (0.39) CYP1A2TDP1HRH4LMNAPHGDH
SCHEMBL17771605 0.82 LMNA (0.39) CYP1A2TDP1HRH4LMNAPHGDH
N-Methylpiperidine SCHEMBL11878290 0.82 LMNA (0.39) CYP1A2TDP1HRH4LMNAPHGDH
SCHEMBL6238723 0.82 LMNA (0.39) CYP1A2TDP1HRH4LMNAPHGDH
SCHEMBL13835190 0.82
SCHEMBL19878898 0.82

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102264732-A Pi3k/mtor kinase inhibitors 2011-11-30 CN claimed
US-20090318424-A1 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2009-12-24 US claimed
US-20090239846-A1 Novel Compounds GLAXO GROUP LIMITED (GB) 2009-09-24 US claimed
US-7541359-B2 N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase JANSSEN PHARMACEUTICA N.V. (BE) 2009-06-02 US claimed
EP-2032142-A2 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2009-03-11 EP claimed
WO-2007147109-A2 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2007-12-21 WO claimed
EP-1866311-A2 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2007-12-19 EP claimed
US-20070004741-A1 N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase APODACA RICHARD 2007-01-04 US claimed
US-20060235030-A1 Novel compounds GLAXO GROUP LIMITED (GB) 2006-10-19 US claimed
WO-2006104889-A2 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2006-10-05 WO claimed
EP-0033255-B1 OXIMES DERIVED FROM ERYTHROMYCIN A, THEIR PREPARATION, THEIR APPLICATION IN PHARMACEUTICALS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ROUSSEL-UCLAF (FR) 1984-08-29 EP claimed
US-20250243194-A1 ANTAGONIST OF ADENOSINE RECEPTORS JANSSEN PHARMACEUTICA NV (BE) 2025-07-31 US disclosed
EP-2300013-B2 PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS TAKEDA PHARMACEUTICALS CO (JP) 2024-11-13 EP disclosed
CN-118530229-A Arctigenin derivative and preparation method and application thereof 深圳市翰林生物医药科技有限公司 2024-08-23 CN disclosed
US-20230181693-A1 METHODS OF TREATING INFLAMMATORY SKIN DISORDERS NEPSONE EHF (IS) 2023-06-15 US disclosed
WO-2006104889-A2 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2006-10-05 WO disclosed
WO-2006104915-A2 8-PHENYL-7,8-DIHYDROPYRIDO[2,3-d]PYRIMIDIN-7-ONES AND THEIR USE AS PHARMACEUTICALS GLAXO GROUP LIMITED (GB) 2006-10-05 WO disclosed
CN-1774435-A 5-membered heterocyclic derivative DAIICHI SEIYAKU CO (JP) 2006-05-17 CN disclosed
EP-1163239-A1 MODIFIED AMINO-ACID AMIDES AS CGRP ANTAGONISTS Boehringer Ingelheim Pharma KG (DE) 2001-12-19 EP disclosed
WO-2000055154-A1 MODIFIED AMINO-ACID AMIDES AS CGRP ANTAGONISTS BOEHRINGER INGELHEIM PHARMA KG (DE) 2000-09-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090239846-A1 Novel Compounds MAPKAPK2, MAPKAPK3, CDC42BPB CYP1A2 4808/4885TDP1 2552/4885HRH4 3226/4885
US-20060235030-A1 Novel compounds MAPKAPK2, MAPKAPK3, CDC42BPB CYP1A2 4808/4885TDP1 2552/4885HRH4 3226/4885
US-20250243194-A1 ANTAGONIST OF ADENOSINE RECEPTORS ADORA2B, ADORA2A, ADORA1 CYP1A2 403/4885TDP1 2277/4885HRH4 218/4885
US-20070004741-A1 N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase FAAH, FAAH2, CNR2 CYP1A2 900/4885TDP1 3958/4885HRH4 11/4885
US-20090318424-A1 NOVEL COMPOUNDS MAPKAPK2, MAPKAPK3, CDC42BPB CYP1A2 4808/4885TDP1 2552/4885HRH4 3226/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.