Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | RARG | P13631 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1460386 | 0.83 | PDE4B (0.44) | PDE4BRIPK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27967501 | 0.83 | MAPK14 (0.43) | NPC1RAB9ASMN1; SMN2NPSR1MAPK14 | |
| SCHEMBL1722408 | 0.82 | MARS1 (0.37) | RIPK1 | |
| SCHEMBL1459190 | 0.81 | PDE4B (0.43) | PDE4BRIPK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2853643 | 0.75 | PDE4B (0.43) | PDE4BRIPK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27629217 | 0.69 | FABP3 (0.51) | ALDH1A1MAPT | |
| SCHEMBL11562429 | 0.68 | SMN1; SMN2 (0.47) | PDE4BNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL10698208 | 0.66 | PDE4B (0.42) | PDE4BRIPK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL702658 | 0.64 | CNR1 (0.48) | — | |
| SCHEMBL4917405 | 0.64 | KDM4E (0.50) | PDE4BRIPK1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349261-A2 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GenKyoTex SA (CH) | 2011-08-03 | — | — | EP | disclosed |
| EP-2344492-A1 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GenKyoTex SA (CH) | 2011-07-20 | — | — | EP | disclosed |
| EP-2305679-A1 | Pyrazoline dione derivatives as nadph oxidase inhibitors | GenKyoTex SA (CH) | 2011-04-06 | — | — | EP | disclosed |
| WO-2011036651-A1 | PYRAZOLINE DIONE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2011-03-31 | — | — | WO | disclosed |